GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeysCyclic adenosine monophosphateantibodycAMPdiet-induced obese miceglucagon-like peptide-1glucose-dependent insulinotropic polypeptidemonkeys...
To test this hypothesis, a series of GIPR antagonist antibodies (GIPR-Ab) conjugated to GLP-1 peptides were created and investigated34. These bispecific molecules that antagonize GIPR and agonize GLP-1R pathways led to decreases in BW and improvements in metabolic parameters in obese mice and ...
2021年,AMGEN发表文章“GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys”,研究表明,用双特异性分子对抗/激活GIPR/GLP1R通路可以降低肥胖小鼠和猴子的体重和代谢参数。机制研究表明,这些分子同时与GIPR和GLP1R结合并触发受体内化,在表达...
6. Fluorescent agonist/antagonist probes Current GLP1R antibodies have variable specificity and, except for the monoclonal antagonistic antibody, can only be used in fixed tissue. On the other hand, Cre reporter approaches allow labeling of Gipr- and Glp1r-expressing cells in live and fixed tissue...