GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeysCyclic adenosine monophosphateantibodycAMPdiet-induced obese miceglucagon-like peptide-1glucose-dependent insulinotropic polypeptidemonkeys...
2021年,AMGEN发表文章“GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys”,研究表明,用双特异性分子对抗/激活GIPR/GLP1R通路可以降低肥胖小鼠和猴子的体重和代谢参数。机制研究表明,这些分子同时与GIPR和GLP1R结合并触发受体内化,在表达...
Lu, S. C. et al. GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.Cell Rep. Med2, 100263 (2021). ArticlePubMedPubMed CentralGoogle Scholar Garg, A. & Balthasar, J. P. Investigation of the influence of FcRn on...