The phase II endpoint was not met and further enrollment has been halted based upon pre-specified study stopping rules utilizing the original assay. No improvement in ctDNA clearance was observed after 6 mos of chemotherapy for...
Functional disturbances in the pharyngeal phase usually manifest as abnormalities in clearance of swallowed boluses from the pharynx. These can be a result of propulsive failure, outflow obstruction, or failure to maintain luminal closure at entrance and exit points to the pharynx. Sensory disturbances...
51 This increased risk is owing to impaired esophageal luminal acid clearance. Nissen fundoplication is the preferred surgical treatment for GERD, postesophageal atresia repair, with a 15% to 30% failure rate and requirement for reoperation.52 Dysphagia, owing to esophageal dysmotility, has been ...
concentration). A clearance of more than 13 mL/24 h is abnormal. 72 Labworkup serum protein electrophoresis, lymphocyte count, and serum cholesterol to look for evidence of lymphatic obstruction Fecal fat Giardiasis/ ova Serum albumin 73
In contiguity (IC) resections of either segment 2 (IC2) or 3 (IC3) or both (IC2 + 3) were done to achieve tumour clearance. Postoperatively, liver function was monitored for at least 1 week.Results: Of the 37 patients who underwent a right trisectionectomy extending beyond the ...
compare ctDNA clearance between Arm A and Arm B among the first 16 pts with ctDNA detected at baseline. If p>35, the study would be stopped for futility of ctDNA clearance but would otherwise continue to phase III if p≤.35. We present the results of the pre-planned phase II ...
no benefit of ACT was observed in MRD- pts (HR=1.1, 95% CI: 0.3-3.9, p=0.89). Of the MRD+ pts, 39.1% (18/46) had ctDNA clearance at 12-weeks post-surgery tp. Pts with ctDNA clearance had longer DFS compared to those who remained positive (median DFS: 24.2 vs 13.8 months; ...
(6.5%), and in genes of the homologous recombinant DNA damage repair pathway (HR-DDR) in 12.3%. In addition, serial measurements with clearance of mTP53 or mKRAS cfDNA seemed to be predictive of increased PFS (HR 0.087 and 0.32 withp = 0.0056 andp = 0.037, respectively) in ...
four major types of dysphagic patterns typically occur: (1) inability to prepare the food orally, (2) inability to initiate the swallow in a timely and coordinated manner, (3) inadequate airway protection or velopharyngeal (VP) closure during the swallow, and (4) incomplete bolus clearance. ...
These include transient lower esophageal sphincter relaxations (as previously described), decreased LES resting tone, delayed stomach emptying and an ineffective esophageal clearance. Certain drugs have had some effectiveness at controlling GERD but fail to treat underlying causes of the disease. Examples...