Timson, D.J., GHMP Kinases - Structures, Mechanisms and Potential for Therapeutically Relevant Inhibition. Current Enzyme Inhibition, 2007(3): p. 77- 94.Timson DJ (2007) GHMP kinases - structures, mechanisms and potential for therapeutically relevant inhibition. Current Enzyme Inhibition 3, 77-94...
GHMPkinasesGene expressionRNA-seq data analysisWheatThe GHMP (galactokinase, homoserine kinase, mevalonate kinase and phosphomevalonate kinase) kinase gene superfamily is a unique class of ATP-dependent enzymes. It plays a role in the metabolism of carbohydrate, biosynthesis of isoprenes, amino acids ...
Because GHMP kinases, thus far, have only been characterized as small molecule kinases involved in metabolic pathways, for example, amino acid and cholesterol synthesis, XOL-1 is the first member that controls nonmetabolic processes. Biochemical investigations demonstrated that XOL-1 does not bind ...
(2011) The role of the active site residues in human galactokinase: implications for the mechanisms of GHMP kinases. Bioorg. Chem. 39, 120-126.MEGARITY CF,HUANG M,WARNOCK C. The role of the active site residues in human galactokinase:implications for the mechanisms of ghmp kinases[J]....
The GHMP genes family, a unique class of ATP-dependent enzymes, consists of galactokinases, homoserine kinases, mevalonate kinases and phosphomevalonate kinase etc. It was implicated in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. Previous studies mainly ...
In the invention, a gossypium hirsutum mitogen-activated protein kinases gene is obtained by adopting homology-based cloning and RACE technology. A cDNA sequence of the gene is positioned below a CaMV35S promoter to construct plant expression vectors and convert nicotiana benthamiana so that the ...