Potential chemotherapeutic interventions against GHMP kinases fall into three main categories: inhibition of galactokinase to assist suffers of galactosemia, inhibition of mevalonate kinase or mevalonate 5-diphosphate decarboxylase to reduce flux through the cholesterol biosynthesis pathway and inhibition of ...
In conclusion, the present study provides novel information, thus enhances our understanding of the GHMP kinase gene family in wheat. The information obtained will be valuable in selecting potential candidate genes in wheat for developing cultivars with improved tolerance against biotic and abiotic ...
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily. J Biol Chem 2002;277:9462-7.Yang D, Shipman LW, Roessner CA, Scott IA, Sacchettini JC, Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase super- ...
GhMPK11基因病原菌抗性GA信号途径促丝裂原活化蛋白激酶生物学功能促丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)是真核生物中普遍存在的一类苏氨酸/酪氨酸双重特异性蛋白激酶,位于MAPK级联信号途径的最下游,可以直接作用于下游靶基因,引起体内的生理生化变化.MAPK级联信号途径广泛参与植物的生长发育,非...
The GHMP genes family, a unique class of ATP-dependent enzymes, consists of galactokinases, homoserine kinases, mevalonate kinases and phosphomevalonate kinase etc. It was implicated in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. Previous studies mainly ...
Mitogen -activated protein kinase ( MAPK ) cascades play a pivotal role in environmental responses and developmental processes in plants. Previous researches mainly focus on the MAPKs in groups A and B, and little is known on group C. In this study, we isolated and characterized GhMPK7 , ...