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纬-Hydroxybutyrate (GHB) is an endogenous metabolite of mammalian brain which is derived from GABA. Much evidence favours its role as an endogenous neuromodulator, synthesized, stored and released at particular synapses expressing specific receptors. One key step for GHB involvement in neurotransmission...
GHB is also a naturally-occurring metabolite of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) found in the brain. The naturally-occurring metabolite GHB is present in much lower concentrations in the brain than those levels found when the drug is abused. As a result of ...
The synthesis of γ-hydroxybutyrate (GHB) from SSA is a minor byproduct pathway from the GABA shunt (Maitre, 1997) (Fig. 1). However, it is known that defective SSADH activity leads to the accumulation of GHB in the brain and provokes γ-hydroxybutyric aciduria (Gordon, 2004; Malaspina et...
Chemically, GHB is closely related to the neurotransmitter gamma-aminobutyric acid (GABA) for which it is both a metabolite and a precursor [2]. GHB is a fast-acting central nervous system depressant. Its half-life of 20–60 min leads to short detection windows of around 6 h in blood ...
关键词: GABA shunt GHB SSA SSADH GHB dehydrogenase uga2 DOI: 10.1007/s11103-016-0475-6 被引量: 8 年份: 2016 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 Springer Springer (全网免费下载) Springer (全网免费下载) 国家科技图书文献中心 (权威机构) 掌桥科研 查看更多 ...
GHB is metabolized to succinic acid by multiple dehydrogenase enzymes. Metabolic precursors to GHB, gamma-butyrolactone (GBL) and 1,4 butanediol are also readily available as substances of abuse. Endogenous GHB is also a product of GABA metabolism and concentrations as high as 6.6 mg/L have been...
(2012) α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci USA 109: 13404–13409 doi:10.1073/pnas.1204376109. [21] Farrant M, Nusser Z (2005) Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat ...
[26] investigated one 10 cm head hair sample, from a 45-year-old man who had undergone sodium oxybate treatment for 6 months. After decontamination, the hair sample was dried and cut into 10 segments of 1 cm each and analyzed for GHB, GHB-glucuronide, GBL and GABA by UHPLC-MS/MS. ...
from the conversion of GHB into GABA and/or GHB-induced stimulation of GABA release in specific brain regions; both phenomena would give rise to a GABA pool which may bind to the GABAA–benzodiazepine receptor complex. A possible, third mechanism is the capacity of GHB to effectively increase,...