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Herpesviruses use envelope glycoproteins to enter host cells, including the viral gB that is necessary for entry into all cell types24. This viral fusogen is highly immunogenic and is the target of neutralizing antibodies25. CMV gH is another dominant target of specific antibodies that can be str...
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The emerging fluorescence was detected by the Orca flash 2.8 sCMOS camera (Hamamatsu) driven by Dalsa Xcelera (Teledyne DALSA) PCIe card mounted on AMD FX-8 core 3.5 GHz, 32 Gb RAM pc running Windows 8.1 (Microsoft). Eight-bit image stacks were calibrated using Rodbard NIH Image curve...
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The initial HSV-1 virion attachment to cells requires an interaction with heparin like cell associated glycosaminoglycans and may be mediated by HSV envelope glycoproteins gB and gC. WuDunn and Spear, J. Virol. (1989) 63:52-58. gB and gD are essential for the secondary interactions at the ...