Chronic kidney disease can progress to the end-stage renal disease (ESRD) characterized by a high risk of morbidity and mortality. ESRD requires immediate therapy or even dialysis or kidney transplantation, therefore, its timely diagnostics is critical for many patients. ESRD is associated with patho...
Since 1957, over 70 equations based on creatinine and/or cystatin C levels have been developed to estimate glomerular filtration rate (GFR). However, whether these equations accurately reflect renal function is debated. In this Perspectives article, we d
(particularly in relation to age-related decline),21 the fact that most estimated GFR equations do not seem to be able to identify most hyperfiltrating patients,94 and that renal function is often standardised for body mass.22 Early biomarkers are thus lacking to identify and stage clinically ...
stage function isthe contl/aonmanifestation abnormity inthe to persons lead,but exposed GFRis in the normal Can not be usedinthe usually stage.4.Iohexol-GFR early only but be to also the hospital appliedepidemical investigation. Key filtration words:high performanceliquid rate; chromatography;...
Results The study included 109 patients with MN (mean age 65 years; 73% male; eGFR 62 ml/min, 36% on renin-angiotensin-aldosterone system inhibitors prebiopsy). EC stages were I, 19%; II, 49%; III, 26%; and IV, 6%. There was no difference in glomerular volume among EC stage ...
Chen DC, Shlipak MG, Scherzer R, et al. Association of intraindividual difference in estimated glomerular filtration rate by creatinine vs cystatin C and end-stage kidney disease and mortality.JAMA Netw Open. 2022;5(2):e2148940. doi: 10.1001/jamanetworkopen.2021.48940. ...
The course of CKD progress rapidly to end-stage renal failure (end-stage renal disease, ESRD),and could further lead to cardiovascular disease (cardiovascular a certain remedy diseases, CVD) and other serious complications. Therefore, accurate measurement of total or differential renal function plays...
originalMDRDequationsacrossCKDstagesinamulticenter,cross-sectionalstudyofGFRestimationfromplasmacreatinine, demographicdata,andclinicalcharacteristics.Atotalof684adultpatientswithCKD,fromninegeographicregionsofChina wereselected.Arandomsampleof454ofthesepatientswereincludedinthetrainingsampleset,andtheremaining230 ...
ACR, albumin-to-creatinine ratio; AKI, acute kidney injury; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; GP cohorts, general population cohorts; HR, hazard ratio; HR cohorts, high-risk cohorts. Interactions The multiplicative interaction between eGFR and albuminuria was...
CircGFRA1 was greatly increased in HCC tissues and cells, and the over-expression of circGFRA1 was intimately related with the advanced clinical stage and poor survival of HCC patients. The expression of circGFRA1 was negatively correlated with the expression of miR-498, but a positive ...