(χ2and Spearman’s tests, Fig.5a, b). The number of significant pairs derived fromχ2tests was nearly double in samples from captive animals than in those from the soil control and free-range samples. Co-occurrence of resistance phenotypes was also differentially distributed within and between...
Human tumors represent complex ecological systems of diverse cell types with dynamic genetic evolution and phenotypic remodeling1,2,3. However, there is a lack of robust methods for tracking both genotypes (e.g., mutations) and phenotypes (e.g., gene expressions, isoforms) of individual cells t...
To predict blood group antigen phenotypes, SNV mapping which involves highly multiplexed genotyping, can be performed on commercial microarray platforms. Microarrays detect only known SNVs, therefore, to type rare or novel alleles not represented in the array, further Sanger sequencing of the region ...
46]. ALS-FUS cases showed predominantly neuronal p62 aggregation within layers I-V in the form of sparse-moderate NCI and DN (Fig.3i, j), although occasional oligodendroglial inclusions were seen. We found rare examples of p62-positive
Muller et al.15 have argued that obesity is such a complex phenotype that studies should concentrate on more specific phenotypes such as one or more in this list, but Speakman et al.13 have counter-argued that an increase in sample numbers might well still provide insights into obesity....
Therefore, considering a potential milder effect of these variants, it may be possible that deeper phenotyping and follow-up would reveal signs of the disease-associated phenotypes in those individuals. Unfortunately, clinical phenotype data is not available for most of the ExAC individuals8 or ...
The phenotypes of these OTUs were then predicted using the BugBase algorithm. Of the 8 derived phenotypes, there was a much greater abundance of bacteria carrying MGEs in samples from captive animal samples than in those from free-range samples (p < 0.001; except for small-scale sheep farming...
5, 6 However, given the unique aspect of certain genes, unknown penetrance, and phenotypic variability of a variant in different genetic backgrounds, the control population may contain individuals with milder phenotypes and/or resilient individuals,7 resulting in misclassification of potentially pathogenic...
In the current work, we aimed to estimate a few image traits associated with phenotypes to understand their variability, and to measure geometrical and physio-morphological characteristics. These traits were, namely, the number of leaves (NL), bounding box area (BBA), convex hull area (CHA), ...