本指导原则为ICH S2A和S2B指导原则的替代和合并。 本次修订的目的是:优化预测潜在人体风险的遗传毒性试验 标准组合;为结果分析提供指导,其最终目标是改进试验对 基于遗传物质改变的致癌性的风险表征能力。本修订版指导 原则描述了对遗传毒性标准试验组合中的体外试验和体内 试验阳性结果的追加试验和分析(包括对不相关发...
(2004): Genotoxicity studies with pure trans-capsaicin. Mutat Res. 557:85-97.Chanda S, Erexson G, Riach C, Innes D, Stevenson F, Murli H, Bley K. Genotoxicity studies with pure trans-capsaicin. Mutat Res Genet Toxicol Environ Mutagen 2004;557:85-97....
Genotoxicity studies of dry extract of Boswellia serrata . Tropical J Pharmaceutical Research. 2008; 7 (4):1129–1135.Magesh V, Raman D, Pudupalayam KT: Genotoxicity studies of dry extract of Boswellia serrata. Tropical J Pharmaceutical Research 2008, 7(4):1129-1135....
Now there are few studies on the joint toxicity of formaldehyde and benzene, especially the reports of joint genotoxicity. 目前有关甲醛和苯联合毒性的研究较少,对遗传毒性的联合效应研究的报道更少。 www.fabiao.net 9. A Study on the General Toxicity and Genotoxicity of Compound Oral Liquid of Tumor...
Lee, Gwan SunHan, Jae YongLee, MichaelLee, Young-MiKoh, Woo SukKim, Ji-YoungTaylor & FrancisDrug & Chemical ToxicologyKwon SC,Lee GS,Han JY, el al.Genotoxicity studies on HM10760A, recombinant human erythropoietin conjugated to globin fragment. Drug and Chemical Toxicology . 2010...
Genotoxicity studies with paracetamol 来自 dx.doi.org 喜欢 0 阅读量: 71 作者:E Dybing,JA Holme,WP Gordon,EJ Søderlund,SD Nelson 摘要: Paracetamol and its major ultimate reactive metabolite, N-acetyl- p-benzoquinone imine (NAPQI) were studied for their genotoxic potential. Neither paracetamol ...
Genotoxicity studies on sertaconazole A series of 6 studies has been performed to evaluate the potential genotoxic effect of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H- imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI 7045, CAS 99592-32-2). From these studies, ... A ...
No Observed Adverse Effect Level (NOAEL)cannot be obtained from mutagenicity/genotoxicity studies due to study design and different mode of action. It is generally assumed that even a small dose of mutagenic (genotoxic) chemicals may have a potential adverse effect. In general, the advice given ...
Direct evidence of EDC genotoxicity was shown in a number of in vitro and in vivo studies measuring effects such as mutations, sister chromatid exchange (SCE) frequency, recombination, micronuclei (MN) induction, DNA strand breaks, and DNA adducts (Table 1). The below discussion summarizes the ...
Our results provide a background for further studies in order to verify the applicability of Comet assay on T. saltator for assessing genotoxicity levels in sandy beaches subjected to pollution.doi:10.1080/24750263.2020.1751887G. Di DonatoD. Davolos...