Genomics, Type 2 Diabetes, and ObesityReynisdottir I
Type 2 diabetes (T2D) and obesity represent major challenges for global public health. They are at the forefront of international efforts to identify the g
Numerous studies have shown that obesity is a major risk factor of T2D onset and progression [6]. Up to 90% of T2D patients are in the overweight or obese category [7, 8]. A growing number of genome wide association studies (GWAS) on diabetes have identified hundreds of T2D-associated ...
Mouse models of diabetes and obesity can serve as convenient platforms to functionally probe a small number of candidate genes [8], but this approach is expensive and slow, limiting the number of genes that can be readily assessed. The biochemical pathways involved in growth and metabolism are ...
precursors, obesity, type II diabetes, dyslipidemia and hypertension (collectively metabolic syndrome).\nGenizon's technology platform and discoveries can complement current R&D programs by using human genetics to significantly enhance research and by adding value at multiple stages of the drug development...
(TTC28-Antisense RNA 1). This long non-coding RNA gene has been shown to be downregulated in type 2 diabetes and decreased expression is potentially related to higher risk of developing type 2 diabetes [41].CDH18(cadherin 18 type 2) is one of the closest genes to rs77388455 on ...
(TTC28-Antisense RNA 1). This long non-coding RNA gene has been shown to be downregulated in type 2 diabetes and decreased expression is potentially related to higher risk of developing type 2 diabetes [41].CDH18(cadherin 18 type 2) is one of the closest genes to rs77388455 on ...
The additional connection between CREB and ER stress revealed by our analysis is especially interesting given the clinical observation that chronic ER stress and overactive hepatic glucose production are both features of type 2 diabetes and obesity [10, 49, 50]. Conclusions Overall, our results ...
期刊名称:《BMC Genomics》 | 2014年第Suppl 2期 10.Nutritional genomics and metabolomics in obesity and type 2 diabetes 机译:肥胖和2型糖尿病的营养基因组学和代谢组学 作者:Frank B Hu;Kothandaraman Narasimhan 期刊名称:《BMC Genomics》 | 2014年第Suppl 2期 11.Epigenetic control of cell identi...
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab. 2006;4:407–14. PubMed CAS Google Scholar Pilegaard H, Richter EA. PGC-1α: important for exercise performance? J Appl Physiol. ...