Epidemic pathogensgene lossgenomicstoxinsvirulenceVirulence factors are thought to be responsible for the virulence capacity of pathogenic bacteria. However, epidemic bacteria were recently found to contain significantly fewer virulence factors than non-epidemic species, and some of the most dangerous ...
Outbreaks in fish of motileAeromonadsepticemia (MAS) caused byAeromonas hydrophilahave caused a great concern worldwide. Here, for the first time, we provide two complete genomes of epidemicA. hydrophilastrains isolated in China. To gain an insight into the pathogenicity of epidemicA. hydrophila,...
Genomic data also provide information on the underlying causes of virulence and transmission of ancient pathogens, as well as the relationship between historical and contemporary lineages. 展开 关键词:genomics genome pathogen plague epidemic ancient DNA ...
J. et al. Salmonella enterica genomes from victims of a major sixteenth-century epidemic in Mexico. Nat. Ecol. Evol. 2, 520–528 (2018). This paper presents the metagenomic tool MALT and is the first case study to demonstrate metagenomic detection of ancient pathogens in the absence of ...
2B). It plays a critical role in regulating and maintaining overall adaptive immune resistance to pathogens and has emerged as a target gene affecting resistance or susceptibility to disease in pigs [22, 23]. Furthermore, GABARAPL1 and GABARAPL2, identified as candidate genes of the EM-...
(Scott and English2008). Likewise, these two pathogens are the major causes of non-epidemic meningitis among children in the developing world, whileNeisseria meningitidisis associated with epidemics, particularly in the Africa meningitis belt (Peltola2001). Several pneumococcal virulence factors have ...
White spot syndrome virus (WSSV) has been one of the most devastating pathogens affecting the global shrimp industry since its initial outbreaks in Asia in the early 1990s. In this study, we recovered 13 complete metagenome-assembled genomes (MAGs) of Japanese WSSV isolates and 30 draft WSSV MA...
Moving forward, we must recognize that we have had a new major coronavirus epidemic every decade in the twenty-first century SARS in the 2000s, MERS in the 2010s, and now COVID-19. It is, therefore, a global security priority to advance coronavirus vaccines and to identify international ...
An epidemic that has grown to span multiple countries or continents, often with many affected individuals. Cluster A group of epidemiologically related cases defined by their relationship in space and time or via molecular methods. Metagenomics ...
Based on comparative genomic and functional analyses, we provide novel insights into the pathogenicity of epidemic A. hydrophila by identifying puta- tive factors that may be involved in the bacterial pathogenicity, and we also determined that the ST251 clonal group of A. hydrophila is likely ...