I noticed a large number of small factual errors in the text, described in the “Validity of the Findings” section. They include mathematical, computational, and conceptual errors. Because I am an expert only in the deep learning half of deep learning for genomics, I can only comment on th...
For 16S, we applied our in-house bioinformatic pipeline to increase the proportion of amplicon sequence variants classified to the species level, in contrast to the conventional strategy [23]. The 16S data was preprocessed as previously described [32]. In brief, the 16S rRNA gene hypervariable V...
What’s more, folic acid (vitamin B9) is an important amino acid that enters the folate synthesis process which is vital for the replication of DNA. This process can be blocked by trimethoprim and sulfamethoxazole. The presence or absence of the folA (dihydrofolate reductase) or the folP (di...
The trade-off to using model organisms is that they are often not “typical” and do not reflect the biology of their close relatives or even the wide diversity of living mechanisms. They also display only a fraction of the traits found in the biosphere, often limited to observations made i...