Genome-Wide Association StudyResearch DesignGenetic Predisposition to DiseaseFemaleMaleSynonyms GWA study ; Whole-genome association study (WGAS) Definition Genome-wide association studies are designed to identify points of common variation in DNA that are associated with particular traits, including ...
GWAS,全称genome-wide association study,即全基因组关联分析。GWAS是一种用于识别遗传区域(基因座)和性状(包括疾病)之间关联的无假设方法, 在群体水平上解析性状遗传基础的方法。这是非常书面的表述,非常绕口和难以理解。 举例来说吧,比如我们在世界上找到了一组身高超过姚明身高的‘小巨人’,身高就是这些‘小巨人...
Synonyms GWA study ; Whole-genome association study (WGAS) Definition Genome-wide association studies are designed to identify points of common variation in DNA that are associated with particular traits, including diseases and responses to medication (Wang, Barratt, Clayton, & Todd, 2005 ). By ...
Martin Tobin and colleagues present genome-wide association studies for pulmonary function as part of the SpiroMeta consortium. Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary
迄今为止,全基因组关联研究(以下简称GWAS)发展已有二十多年了。这二十多年间,随着样本数的越来越大以及基因芯片的物美价廉,GWAS也得到了更多的发展,科学家们发现了大量和人类疾病以及其它表型相关联的基因,在此基础上,GWAS还推动了孟德尔随机化和多基因风险评分的发展与应用。可以说,GWAS是现代遗传学的重要组成部分,...
Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of European ancestry: CD247, NA
9780199390069 Find at OUP.com Google Preview Genome-Wide Association Study (GWAS)(Syn:whole genome association study, WGA study) AnAssociation studyin which numerous genetic variants across the genome are analyzed to measure differences associated with aTrait... Access...
The genome-wide association study The genome wide association study (GWAS) provides a radical alternative to the candidate gene approach[25]. The GWAS makes use of the fact thatSNPscluster into haplotypes due tolinkage disequilibrium. This means that the majority of the estimated 11 million...
主持人:侯琳 教授报告人:赵宏宇 教授主题:Genome wide association study专题介绍 10:15-10:30主持人:吕琼石 教授报告人:潘伟 教授主题:Integrating brain imaging endophenotypes with GWAS for Alzheimer’s disease 10:30-10:45报告人:何子淮 教授主题:Genome-wide analysis of common and rare variants via ...
Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants Cerebral small vessel disease (CSVD) is a major cause of stroke and associated with structural changes of the brain. Here, Persyn et al. perform genome-wide association studies for magnetic reson...