The performance assessment was also based on determining the area under the receiver operating characteristic curve (AUC) for each model and was calculated using R (ver. 3.4.0) to determine whether the two PGS are translatable in the QBB cohort....
Prospective analyses were then conducted to determine associations of identified metabolites with incident diabetes over 12 years of follow-up in 694 participants (391 women from WIHS and 303 men from the Multicenter AIDS Cohort Study; 166 incident cases were recorded) with and without HIV infection...
Multi-way ADONIS permutation-based statistical test was applied to determine whether gut microbiome was associated with PhenoAgeAccel after adjusting for the effects of covariates in vegan-R. The gut microbes associated with PhenoAgeAccel were identified using a Random Forest Regressor with q2-sample-...
Genome-wide association studies (GWASs) of medication use may contribute to understanding of disease etiology, could generate new leads relevant for drug discovery and can be used to quantify future risk of medication taking. Here, we conduct G
We also used the cutoff value provided by the kit company to determine whether the subject was in a TPOAb positivity state.In the Longgang study, thyroid function tests measured concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and anti-TPOAb. These measurements were ...
s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment...
the gap statistic curve. The gap statistic was calculated for cluster numbers ranging from k = 1 to 20, and the slope of the gap statistic curve was utilized to determine the optimal number of clusters. Visualization of phenotypic similarity scores across distinctMECP2proband groups and ...
CellTiter-Glo luminescence assay (Promega, Madison, WI) was used to determine the suppressive effect of the corresponding drug on the control or gene-edited cell line. The cells were distributed at 2000 cells per well on a 96-well plate. The cells were exposed to the appropriate drugs in a...
To determine which of the 2030 association signals are distinct from previous metabolite GWAS findings, we repeated metabolite association analysis conditioning on all variants that were (a) ≤ 1 Mb of the index variant and (b) previously reported as associated with any metabolite in a cura...
Leveraging publicly available GWAS summary-level data12,13,14(Supplementary Data1, “Methods”), we conducted cross-trait linkage disequilibrium (LD) score regression (LDSR) analysis15,16to determine whether there was a shared genetic contribution between polygenic phenotypes for multiple diseases and ...