Over the past decade, long-read, single-molecule DNA sequencing technologies have emerged as powerful players in genomics. With the ability to generate reads tens to thousands of kilobases in length with an accuracy approaching that of short-read sequencing technologies, these platforms have proven ...
Sequencing projects have traditionally used long (400–800 base pair) reads, but the existence of reference sequences for the human and many other genomes makes it possible to develop new, fast approaches to re-sequencing, whereby shorter reads are compared to a reference to identify intraspecies...
Momentum [主语] quickly [状语] built up [谓语] behind the Human Genome Project and its objective of "sequencing" the entire genome [状语] ---writing out all the letters in their correct order. [同位语] [注:writing out all the letters in their correct order是"sequencing" the entire genome...
Two decades ago, the Human Genome Project (HGP) announced its initial results — the genome sequence and genetic map of the human body. Since then, advances in big data, storage, and computing technologies have ushered in a digital genomic era. Genome sequencing has advanced the study of gene...
"Moving forward, we will conduct further parsing and annotation of T2T-YAO, so that it can be better used in clinical settings," said Kang. He hopes to pioneer sequencing techniques, genomic analyses and diagnostic tools based on an indigenous reference genome to better serve Chinese people, an...
using long-read sequencing and Hi-C technologies, we constructed a chromosomal-level genome ofT. mongolicusand revealed its genomic features, evolutionary history, and phylogenetic position within the Lamiaceae family. Furthermore, combined transcriptomic and metabolomic analyses were conducted to elucidate ...
If you input an assembly graph assembled from total DNA sequencing using third-party a de novo assembler (e.g. Velvet), the assembly graph may includes a great amount of non-target contigs. You may want to use --min-depth and --max-depth to greatly reduce the computational burden for ...
Distilling biologically meaningful information from cancer genome sequencing data requires comprehensive identification of somatic alterations using rigorous computational methods. As the amount and complexity of sequencing data have increased, so has the number of tools for analysing them. Here, we describe...
Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific ...
Whole-genome sequencing of native M. loti strain R7A by the JGI GEBA project and various research findings related to R7A, such as genomic island mobility [12], the NifA-RpoN regulon and its symbiotic activation [13], and the role of the type-IV secretion system in genomic islands [14...