cancer genomesomatic mutationdriver mutationwhole genome resequencingnext generation sequencing technologiesThe recent advances in high-throughput sequencing technologies have enabled several whole cancer genomes to be sequenced. In addition, a number of large-scale targeted resequencing studies have also been ...
Cancer Genome Sequencing Overview Whole genome sequencing (WGS) is a method of next generation sequencing that can provide comprehensive genomic data. Sequencing a cancer patient's whole genome may help researchers better understand the genetic components of cancer pathogenesis, including heritability and ...
only one patient in 300 will be diagnosed with cancer per year. Nevertheless, they all have to go through intrusive monitoring procedures every two years. This surveillance can be uncomfortable, stressful, and time-consuming for the patients, and it places...
The recent advances in high-throughput sequencing technologies have enabled several whole cancer genomes to be sequenced. In addition, a number of large-scale targeted resequencing studies have also been performed previously using Sanger sequencing methods. These studies have identified numerous somatic mut...
Cancer genome sequencing and functional genomics: from translational to clinical medicine. Pharmacogenomics. 2011 Oct;12(10):1371-4... Roukos,H Dimitrios - 《Pharmacogenomics》 被引量: 4发表: 2011年 Motivators for participation in a whole-genome sequencing study: implications for translational genomi...
Cancer genome sequencing--an interim analysis. With the publishing of the first complete whole genome of a human cancer and its paired normal, we have passed a key milestone in the cancer genome sequenc... Edward,J,Fox,... - 《Cancer Research》 被引量: 310发表: 2009年 Molecular ...
Distilling biologically meaningful information from cancer genome sequencing data requires comprehensive identification of somatic alterations using rigorous computational methods. As the amount and complexity of sequencing data have increased, so has the number of tools for analysing them. Here, we describe...
The translation of genome sequencing into routine health care has been slow, partly because of concerns about affordability. The aspirational cost of sequencing a genome is $1000, but there is little evidence to support this estimate. We estimate the cos
The researchers conducted whole genome sequencing (WGS), whole exome sequencing (WES), and RNA sequencing of the patients' tumors, as well as WGS and WES of non-cancerous tissue from the same patient. WGS involves sequencing of the patient's completegenome, while WES involves sequencing those...
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different types of cancer, chronic lymphocytic leukaemia and medulloblastoma, we conduct a...