Here, we review the data regarding this enigmatic phase and discuss similarities and differences between species. We also consider mechanisms that may be responsible for the formation of the uniform chromatin architecture. The uniform organization of chromosomes during early development may serve as an ...
Specifically, we discuss the dynamics of 3D chromatin and genome organization during gametogenesis, embryonic development, lineage commitment and stem cell differentiation, and focus on the functions of chromatin architecture in transcription regulation. Finally, we discuss the role of 3D genome alterations...
Rye is well known for its strong tolerance to abiotic stresses and high adaptability to barren soils2,5. It is also characterized by potent resistance to many fungal diseases, which often elicit severe economic losses in global Triticeae crops4,6. The disease-resistance genes carried by the rye...
Phytophthora infestans is the most devastating pathogen of potato and a model organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host plants. The P. infestans genome experienced a repeat-driven expansion relative to
Similarly, manipulating transcriptional regulation or chromatin states at particular loci can reveal how genetic material is organized and utilized within a cell, illuminating relationships between the architecture of the genome and its functions. In biotechnology, precise manipulation of genetic building ...
The team from Huazhong Agricultural University in central China's Hubei Province aimed to investigate the genome architecture and its effects on the growth of rice through the map. The study will help reveal the genome architecture of rice and promote research on the genetic improvement of rice an...
Lineage-specific genome architecture links enhancers and non-coding disease variants to target gene promoters. Cell. 2016;167:1369–1384.e19. Article CAS PubMed PubMed Central Google Scholar Ernst J, Kellis M. ChromHMM: automating chromatin-state discovery and characterization. Nat Methods. 2012;...
than in galeomorph sharks and were unconnected to evolutionary changes in the karyotype architecture, which were dominated by descending disploidy events. Genome size was positively correlated with cell and nucleus sizes and negatively with metabolic rate. The metabolic constraints on increasing genome ...
Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function. To study the causal relati...
The role of 3D genome organization in development and cell differentiation. Nat. Rev. Mol. Cell Biol. 34, 903–916 (2019). Google Scholar Dixon, J. R. et al. Chromatin architecture reorganization during stem cell differentiation. Nature 518, 331–336 (2015). CAS PubMed PubMed Central ...