The 3D structure and expression changes of multiple myeloma-related genes.aGene pathway enrichment analysis for the switched on/off genes. Switched on genes are defined when their genomic compartment changed fro
9. Jin S, Zhang L, Nie Q: scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles.Genome Biol2020, 21:25. 10. Gong B, Zhou Y, Purdom E: Cobolt: ...
Unified sequence-based association tests allowing for multiple functional annotations and meta-analysis of noncoding variation in Metabochip data. Am. J. Hum. Genet. 101, 340–352 (2017). Article CAS PubMed PubMed Central Google Scholar Ma, Y. & Wei, P. FunSPU: a versatile and adaptive...
Comparative analysis was conducted using the genomes of multiple members of all four L. pneumophila subspecies. Whereas each subspecies forms a distinct phylogenetic clade within the L. pneumophila species, they share more average nucleotide identity with each other than with other Legionella species. ...
Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, et al: Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci USA. 2005, 102: 13950...
of BIAs inT. cordifolia, two genes, Tyrosine decarboxylase (TYDC) and Canadine synthase (CAS), showed multiple signatures of adaptive evolution. Additionally, tyrosine aminotransferase (TAT) showed unique amino acid substitutions inT. cordifolia. The analysis of orthologous genes found seven genes (4...
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the...
近日,美国弗雷德里克国家癌症研究实验室、洛马琳达大学基因组学研究中心等机构的研究人员合作在Genome Biology上发表了题为“Structural variant analysis of a cancer reference cell line sample using multiple sequencing technologies”的研究文章。研究团队通过多种NGS平台系统地研究了参考癌症细胞系中的体细胞SV,并将其与...
Analysis of the RNA-seq data RNA-seq数据的实际分析因其应用场景的不同而存在着各种不同的方法。在本节中,我们介绍了典型RNA-seq实验的所有主要分析步骤,包括质量控制、有/无参考基因组的读序比对、基因和转录本表达度测量指标的获取以及差异基因表达的检测方法。我们还讨论了RNA-seq在可变剪接、融合转录本和小...
Currently, most tools are focused on SNVs and CNAs; to take full advantage of WGS data, tools for visualizing various types of SVs and for the integrative analysis of multiple data types will be helpful. Conclusions and perspectives In the last decade, we have witnessed tremendous growth in ...