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We review here the various applications of mNGS currently being exploited in clinical and public health settings. We discuss the challenges involved in the adoption of mNGS in the clinical laboratory, including validation and regulatory considerations that extend beyond its initial development in research...
Review of the growth of successive editions of MIM provides an opportunity to engage in some scientometrics. As indicated by the original subtitle “Catalogs of Autosomal Dominant, Autosomal Recessive, and X-linked Phenotypes,” MIM was an encyclopedia of phenotypes—genetic traits and disorders. But...
2: 9Eb Peer review 1 two from: speaking at meetings/conferences, posting papers on the Internet, publishing scientific papers in journals and magazines 2 hypothesis – an idea about how something works that can be tested using experiments; conclusion ...
doi:10.1136/jmedgenet-2013-101713 Review answer will be 'yes, because the patient has two monogenic dis- eases simultaneously'.38 Here, the focus is on cases where the answer is 'yes, because there is DI of one disease'. I was sur- prised to find only one study through 2012 where ...
Heredity (2013) 111, 456–466 & 2013 Macmillan Publishers Limited All rights reserved 0018-067X/13 www.nature.com/hdy REVIEW Key questions in the genetics and genomics of eco-evolutionary dynamics AP Hendry Increasing acceptance that evolution can be 'rapid' (or 'contemporary') has generated ...
The impact of this expansion on Island Southeast Asia will be discussed in the next section, while here, we review key points concerning Near and Remote Oceania. While the first Paleolithic expansion into Near Oceania brought modern humans to Australia, New Guinea, and the nearby archipelagos (...
Plasmacytoid dendritic cells (pDCs) are the main source of type I interferon (IFN-I) during viral infections. Their other functions are debated, due to a lack of tools to identify and target them in vivo without affecting pDC-like cells and transitional
A summary of key points is given at the end of the review. Author's response Thank you. I address the problems, questions and misgivings below and in the text as appropriate The first section is entitled "The origin of the eukaryotic cell was a unique event". I am not at all ...
Work performed in the laboratories has been compliant with the Institutional Review Board directives for the experimental work and use of data. Nomaly framework The framework consists of two primary parts: the predictive algorithm and the confirmation of predictions (Fig. 2). The algorithm takes an...