A large-scale international study involving more than 300 researchers, published today in Nature, heralds the discovery of 83 genetic variations controlling human height. To discover the 83 genetic variations, the research team measured the presence of 250,000 genetic variations in the study's 700,...
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find
A primary goal of human genetics is to identify DNA sequence variants that influence biomedical traits, particularly those related to the onset and progression of human disease. Over the past 25 years, progress in realizing this objective has been transformed by advances in technology, foundational ...
Genetics is the study of genes and the variation of characteristics that are influenced by genes—including physical and psychological characteristics. All human traits, from one's height to one's fear of heights, are driven by a complex interplay betwee
Association between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone(PTH)/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activity[J]. J Clin Endocrinol Metab, 2002, 87(4):1791-1796. 更多......
Following the lead of Margery Shaw (personal communication, 1971), I divide the history of human cytogenetics into five ages (1) 1882–1956 (gestation), the period from the first publication on human chromosomes to the reports of the correct chromosome number; (2) 1956–1966 (a golden age...
Lango Allen H, Estrada K, Lettre G et al (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832–838 PubMed CAS Google Scholar Lasky-Su JA, Faraone SV, Glatt SJ et al (2005) Meta-analysis of the association between two polymorph...
et al. Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nat. Genet. 49, 1107–1112 (2017). This is the GWAS origin of IQ2 GPS, which increases the prediction of intelligence from 1% to 3%. CAS PubMed PubMed Central ...
Geneticsis the study of the patterns of inheritance of specific traits. 遗传学是对特征的遗传模式的研究. 期刊摘选 His seminal research ingeneticsrevolutionized the treatment of cancer. 他在基因学上的重要研究改革了癌症的疗法. 期刊摘选 The human hologram holds a master set of keys for all humangen...
The physiology of energy balance is complex, with the arcuate nucleus of the hypothalamus having a central role in this mechanism. Mouse models have been useful in initially highlighting many of the genes and proteins that are involved. Rare, monogenic forms of human obesity — such as mutations...