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large transcriptome studies are essential. Here we describe the transcriptome analysis of 255 primary human microglial samples isolated at autopsy from multiple brain regions of 100 individuals. We performed systematic analyses to investigate various aspects of microglial heterogeneities, including brain region...
for biological discovery. Such screens genetically perturb many genes in parallel and use single-cell RNA sequencing to assess the transcriptomic effects. Now, an in vivo protocol facilitates screens in mouse brain, using adeno-associated virus with transposon-based delivery of the CRISPR guide RNAs....
An atlas of cells in the human brain’s control hub A comprehensive atlas of the human hypothalamus, a brain region that regulates many bodily functions, including temperature, sleep and appetite, has been built using single-cell RNA sequencing and spatial transcriptomics. The atlas reveals previo...
Gosso MF, de Geus EJ, Polderman TJ, Boomsma DI, Posthuma D, Heutink P (2007) Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. BMC Med Genet 8:66 PubMedGoogle Scholar ...
Recently, the development of a new technology, comparative genomic hybridization, which characterizes the copy number of long stretches of DNA along tumor cell chromosomes, has led to the recognition that there is much more gene amplification in astrocytic brain tumors than previously appreciated.5The...
One of the most heavily debated topics in biology and psychology is whether human development is more affected by "nature" or n"nurture". Nature describes what a person is born with, including all of their inherited traits. Nurture describes a person's upbringing, how their interaction with ot...
Oncogenes are qualities that advance cell development and propagation. Tumor suppressor genes are genes that restrain cell division and survival. Harmful change can happen through the arrangement of novel oncogenes, the unseemly finished articulation of ordinary oncogenes, or by the under-articulation ...
Human genetics is the study of the human genome and the transmission of genes from one generation to the next. The human genome consists of 23 pairs of chromosomes (22 pairs of homologous chromosom...
R. et al. The support of human genetic evidence for approved drug indications. Nat. Genet. 47, 856–860 (2015). This study found that development of drugs supported by genetic evidence of mechanism could double the success rate. Article CAS PubMed Google Scholar Declerck, K. & Vanden ...