HumansDiseaseBody HeightGrowth and DevelopmentQuantitative Trait, HeritableMutationGenome-Wide Association StudyHuman height is a highly heritable, classic polygenic trait. Until recently, there had been limited success in identifying the specific genetic variants that explain normal variation of human height...
Biochemical ‘DNA methylation’ marks are found across the genome in vertebrate animals, but in the early embryos of placental mammals, such as mice and humans, they are largely erased in a ‘system reset’. Surveying DNA methylation in opossum embryos reveals that, in marsupials, such marks ar...
University of Basel)J. Gray Camp团队,德国亥姆霍兹慕尼黑研究中心(Helmholtz Munich)Fabian Theis团队,以及瑞士苏黎世联邦理工学院(ETH Zurich)Barbara Treutlein团队合作,在Nature Genetics发表了题为An integrated transcriptomic cell atlas of hum...
Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find
The “Philadelphia chromosome” was found in chronic myelogenous leukemia, one of the first pieces of evidence in humans supporting the chromosome theory of cancer (18). Sign in to download full-size image FIGURE 1-33. Mary Lyon (center) with Wesley Whitten at Bar Harbor, 1971. By 1991, ...
i'm so short. well, height is truly an amazing trait because it's super polygenic. that means many, many different places in the genome contribute to height. we think that we can explain about 50% of the contributions to height based on genes alone. well, what about the other 50%?
A population is defined as a group of interbreeding individuals that exist together at the same time. Genetic variation refers to the degree of difference found among individuals, for instance in height, coat color, or other less observable traits. The particular set of genes carried by an ...
regulated by context-specific patterns of chromatin marks in embryonic stem cells [16], and TE-driven DNA methylation allows genome expansion [17]. In spite of the abundance of research on the roles of TE on the genome biology in humans, model organisms (e.g., mice andDrosophila), and ...
SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for human height explained by 294,831 SNPs genotyped on 3,925...
The combination of mQTLs with genetic and health information from 450,000 UK Biobank participants illuminated metabolic mediators, and hence, novel urinary biomarkers of disease risk. This comprehensive resource of genetic targets and their substrates is informative for ADME processes in humans and is ...