The risk of Alzheimer's disease and other subtypes of dementia is determined by multiple pathways including genetic, environmental and lifestyle factors. With higher risk in socioeconomically deprived individuals, it remains unclear whet... M Klee,A Leist,M Veldsman,... - 《Alzheimers & Dementia...
Cells are minimal functional units in biological phenomena, and therefore single-cell analysis is needed to understand the molecular behavior leading to cellular function in organisms. In addition, omics analysis technology can be used to identify essent
A role for oxidative stress has been proposed both in Alzheimer's disease (AD), associated with amy- loid plaques[21,22], and in Parkinson's disease, with the presence of iron and auto-oxidised monoamines[23]. A role for oxidative stress has also been proposed in mild cognitive ...
Ma, S. et al. Chromatin potential identified by shared single-cell profiling of RNA and chromatin.Cell183, 1103–1116.e20 (2020).SHARE-seq is a powerful method to profile gene expression and chromatin accessibility in the same cell; combining both layers of information shows that changes in e...
The SNP inAPOEwith the lowestPvalue for association with LST is rs429358, for which the C allele associated with lower LST was previously associated with higher self-reported MVPA13and forms part of the Ɛ4 risk allele for Alzheimer’s disease (Discussion). The SNP with the lowestPvalue ...
Lipids and Alzheimer's Disease Akhlaq A. Farooqui, ... Tahira Farooqui, in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010 In neural cell cultures at plasma membrane level, low levels of ceramide mediate differentiation and neuritic outgrowth through it action...
disease, or, alternatively, that the role for CVs in limited (Figure1). Second, using unaffected relatives as controls, who under some models may harbor a sub-threshold genetic load of associated variants, would decrease the association signal. Studies of endophenotypes or intermediate phenotypes ...
Migraine is a complex neurovascular disorder with a strong genetic component. There are rare monogenic forms of migraine, as well as more common polygenic forms; research into the genes involved in both types has provided insights into the many contribut
J.S. and J.L. provided the summary statistics of Alzheimer’s disease. K.K. and N.S. provided the imputed BLUEPRINT genotype data. N.P. preprocessed the iPSDMac RNA-seq data. J.S.P. and O.A.B. performed the RNAscope and immunohistochemistry assay. A.M.H.Y., N.K., R.J.M...
The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly affects the host respiratory system with ~ 80% asymptomatic or mil