Overexpression of ABCB1 has been linked to the development of chemotherapy resistance across these cancers. In vitro work across a wide range of drug-sensitive and -resistant cancer cell lines has shown that upon treatment with chemotherapeutic agents such as doxorubicin, cisplatin, and paclitaxel, ...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform clinical management or therapeutic development. Here, we construct a high-resolution molecular landscape of the cellular subtype...
Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims of this study were to evaluate the frequencies of CYP2C19 and ABCB1 polymorphisms and to identify the clopidogrel-predicted metabolic phenotypes according...
Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc. Natl Acad. Sci. USA 112, 201508736 (2015). This study delineates a method that can identify the organ-specific origin of circulating cfDNA in transplantation. ...
Genekor specializes in Precision medicine, performing gene tests for cancer, cardiovascular diseases, etc.
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor al
Alzheimer’s disease (AD) is a neurodegenerative disorder, most cases of which lack a clear causative event. This has made the disease difficult to characterize and, thus, diagnose. Although some cases are genetically linked, there are many diseases and
The knowledge that cancer is a malignant form of uncontrolled growth has existed for over a century. Several biological, chemical, and physical agents have been implicated in cancer causation. However, the mechanisms responsible for this uninhibited prol
Understanding chronic postsurgical pain is essential for effective pain management.We aimed to assess the prevalence of chronic postsurgical pain in cancer patients and the associated symptom burden.This study was carried out at a tertiary cancer center. It was a cross-sectional study.Participants who...
et al. Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Hum. Mol. Genet. 24, 3582–3594 (2015). Article CAS PubMed PubMed Central Google Scholar ...