Resolving maternal–fetal effect origin The genetic effects on pregnancy traits may be driven by two correlated genomes: the maternal and the fetal. To investigate whether the gestational duration signals originate in either or both genomes, we used phased genotype data to estimate the effects of th...
For the caQTL effect size direction, we considered the RASQUAL Pi statistic. The RASQUAL Pi statistic can range from 0–1, where Pi < 0.5 reflects lower peak accessibility for the alternative allele and Pi > 0.5 reflects higher accessibility for the alternative allele. The effect sizes for ...
The Gut Microbiome--Human Body Symbiosis: Relevance of the Ubiquitous Microbial Community on Health and Development, Part 1 A key motivation behind gut microbiome research is to confirm the cause-and-effect role of the gut microbiota on host health homeostasis. Today, gut ... SS Dutt - 《Amwa...
Scientists don't know why the hippocampus may be smaller in some people with depression. But some research shows that the stress hormone cortisol is produced in excess in depressed people, and cortisol has a toxic or "shrinking" effect on he hippocampus. Some experts think depressed people may ...
To study the interaction between host genetics and diet and its effect on the composition of microbiome in the gut, we performed QTL mapping. As the resolution of QTL mapping depends on the number of recombination events in the studied population, and on the effect size of the QTL, many tho...
Fetal origins of mental health: the developmental origins of health and disease hypothesis. Am J Psychiatry. 2017;174:319–28. Article PubMed Google Scholar Xu XF, Li YJ, Sheng YJ, Liu JL, Tang LF, Chen ZM. Effect of low birth weight on childhood asthma: a meta-analysis. BMC Pediatr...
Although the effect of increased response rates on the principal outcome variable in this study was minimal, this may not be the case for other studies. Every effort should be made to attain as high a response rate as is practical and to establish that respondents are representative of the ...
Funding: This work was supported by the National Institutes of Health [grant numbers xxxx, yyyy]; the Bill & Melinda Gates Foundation, Seattle, WA [grant number zzzz]; and the United States Institutes of Peace [grant number aaaa]. It is not necessary to include detailed descriptions on the...
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada Michael Lerro & France Gagnon Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland Richa Gupta, Sailalitha Bollepalli, Miina Ollikainen & Jaakko Kaprio ...
An interaction on an additive scale occurs when the combined effect of the risk factors differs with regards to the sum of the individual effects, whereas an interaction on a multiplicative scales occurs when the combined effect of the risk factors differs with regards to the product of the ...