dominant, or combined recessive and dominant. When run in the additive, recessive and dominant mode, BridGE tests all SNP pairs across the two pathways using the same disease model. In the combined recessive and dominant mode, BridGE integrates edges derived from multiple disease models, which all...
Genetic variation, which is generated by mutation, recombination and gene flow, can reduce the mean fitness of a population, both now and in the future. This ‘genetic load’ has been estimated in a wide range of animal taxa using various approaches. Adv
a distinction can be made between winter (recessive) and spring (dominant) cultivars, while genotypes with a facultative growth habit have various combinations of dominant and recessive alleles. The influence of the dominant alleles of these genes in spring forms means that the plants...
Of course, we don’t know anything about Susie’s other grandparents, if Susie’s parents share ancestors, recessive/dominant genes or even how many genetic locations are involved with the inheritance of “dimples,” but I digress. DNA skipping generations is a fallacy. You cannot legitimately ...
Rare diseases (RD) affect a small number of people compared to the general population and are mostly genetic in origin. The first clinical signs often appear at birth or in childhood, and patients endure high levels of pain and progressive loss of autono
Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) are highly heritable traits that are used clinically to evaluate risk for cardiovascular disease in humans. In this study, we applied a ...
Under the dominant model, RS1–310, the shorter allele, was preferentially transmitted. The FBAT showed that the rs7294536 A allele was also preferentially transmitted in an additive and dominant model under the bi-allelic mode. When quantitative traits were used in the FBAT, rs7294536 and rs...
(ACME) sizes, we found a significant effect for both the dominant model (ACMEβ = 1.16 × 10−4; 95% CI = [5.19 × 10−5, 1.99 × 10−4];P = 4 × 10−5) and the recessive model (ACMEβ = 1.55 × 10−4; 95% CI = [3.96...
It is often stated that a person is more than a sum of his or her genes. However, it could also be argued that the personal integrity does not consist only of the 'sum', but also of specific traits which in some cases are determined by genes in such a way that it may threaten the...
Public discussion about the inheritance of disease and non-disease traits in humans began in the nineteenth century England, led by the polymath Francis Galton. From its beginning, it was associated with attempts to improve society through selective breeding, as if mankind was another farmyard ...