The main conclusion of this review is that vulnerability to drug addiction suggests an interaction between many brain systems (including the reward, decision-making, serotonergic, oxytocin, interoceptive insula,
Genetic studies of gestational duration may prove useful in the discovery of drug targets as tocolytic agents or for labor induction. At the same time, the genetic effects on gestational duration and preterm delivery are largely similar; this is opposed to the heterogeneity observed at the ...
This national collaborative study is supported by NIH Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). Additional support for this project came from NIAAA award R01AA028064 to JES. The content is solely the...
Common liability to addiction and “gateway hypothesis”: theoretical, empirical and evolutionary perspective. Drug Alcohol Depend. 2012;123:S3–17. Article PubMed PubMed Central Google Scholar Chang LH, Ong JS, An J, Verweij KJH, Vink JM, Pasman J, et al. Investigating the genetic and ...
Genetic contributions to predisposition have been explored to a limited extent, but important insight has come from investigating gene expression, biochemical markers and physiological effects of pre- and postnatal alcohol exposure. These are mediated through pathogenic mechanisms that involve many pathways ...
It has been suggested that oxidative mechan- isms mediate the processes of drug addiction and toxicity [9,10] and that antioxidants may have therapeutic poten- tial in managing these conditions. Little has been pub- lished on ADAMTSL3, although the ADAM gene family has been associated with ...
One of the most transformative applications of genetic testing lies in its ability to address denial, a hallmark of addiction. Many patients resist acknowledging their condition due to stigma or misconceptions. Genetic evidence offers objective proof of predisposition, helping patients understand that thei...
experience show that predisposition to addiction has agenetic basis, and that this interacts with environmental factors such as patterns of drug use. The sensation-seeking trait was predictive of rats' likelihood to exhibit stronger motivation for drugs when we gave them the opportunity to take ...
Early-Stage Breast Cancer JAMA Oncology Brief Report May 1, 2020 This secondary analysis of a randomized clinical trial assesses treatment outcomes in women with different biological types of breast cancer according to germline variant status of BRCA1/2 and non-BRCA1/2 breast cancer predisposition ...
drug addiction (1) drug development (1) drug discovery (1) drug pipeline (1) drug-drug interactions (1) Duchenne muscular dystrophy (5) Duvystat (1) dystopia (3) Ebola (5) ectodermal dysplasia (1) Ed Vargo (1) eDNA (2) Edward Jenner (1) Edwards syndrome (1) ...