Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat. Genet. 47, 1282–1293 (2015). Article CAS PubMed PubMed Central Google Scholar Chung, C.M. et al. A genome-wide association study reveals a ...
Estimation of genetically driven DNA methylation Fig. 1: Estimation of genetically driven DNAm for genetic association testing with complex traits. Full size image Fig. 2: Comparison of average fraction of variance of DNAm variance explained by penalized multiple or univariate regression. ...
The between-study heterogeneity was assessed by Cochran’s chi-square-basedQ-test andI2index. It is considered statistically significant whenp-value <0.05 and/orI2index >50% [33]. The publication bias assessment was done when at least six studies were pooled for meta-analysis. The evaluation...
DNA methylation disruption reshapes the hematopoietic differentiation landscape. Nat. Genet. 52, 378–387 (2020). Article CAS PubMed PubMed Central Google Scholar Gumuser, E. D. et al. Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic ...
Zhu H, Wicker NJ, Shaw GM, Lammer EJ, Hendricks K, Suarez L, Canfield M, Finnell RH: Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Mol Genet Metab. 2003, 78 (3): 216-221. 10.1016/S1096-7192(03)00008-8. Article CAS PubMed Google Scholar ...
coli, providing data on lineages, resistance and virulence features that are often involved in human and animal diseases, in addition to those isolates which are not typable by the standard PFGE method due to DNA methylation [52,53,54]. MLST genotyping revealed wide genetic diversity also ...
Another study [48] used a genome-wide methylation approach to test the influence of DNA methylation status on curve severity, by studying DNA from peripheral blood cells of eight monozygotic twin pairs. The authors found four probes (cg02477677, cg12922161, cg16382077, and cg08826461) where incr...
The study aimed to explore the associations between the interactions of serum vitamin B2 or B12 levels, aberrant DNA methylation of p16 or p53 and MTHFR C677T polymorphism and the risks of esophageal squamous cell carcinoma (ESCC) and esophageal precance
Right, COLGALT2 expression in SW982 synovial cells following editing of DNA methylation with gRNAs. Values were normalised to the mean values of control cells (each n = 3). *P < 0.05; **P < 0.01, calculated by paired t-test Full size image In the dCas9-DNMT3a experiment...
The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. Mol Cancer. 2012;11:40. Article CAS PubMed PubMed Central Google Scholar Lee CK, Lee JH, Lee MG, Jeong SI, Ha TK, Kang MJ, et al. Epigenetic inactivation of the NORE1 gene ...