M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011). Article CAS PubMed PubMed Central Google Scholar Bulik-Sullivan, B. K. et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet....
In addition, an easy-to-use and benchmarked tool to conduct the cell type specificity analysis based on GWAS is not available, which hampers replication of published studies. In this study, we address the current limited use of publicly available scRNA datasets, and propose a workflow to ...
. SNP discovery and mapping carried out by Bordat et al. (2011), using 214 EST-derived markers, resulted in a resource to deploy in silico mapping of 5,460 pea unigenes using genomic resources developed in the model legumeMedicago truncatula. More recently, it has been possible to generate...
Genetic inteRaction and EssenTiality mApper (GRETTA) is an R package that leverages data generated by theCancer Dependency Map (DepMap) projectto perform in-silico genetic knockout screens and map essentiality networks. A manuscript describing this tool is available atbioinformatics (Takemon, Y. and ...
Barbato M, Orozco-terWengel P, Tapio M, Bruford MW (2015) SNeP: a tool to estimate trends in recent effective population size trajectories using genome-wide SNP data. Front Genet 6:109 PubMed PubMed Central Google Scholar Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate...
The majority (64.9%) of these distortions were localized to the mapping family 103×102 and to linkage groups 2, 4 and 10. As no significant family specific heterogeneity was detected for these distortions, they are not thought to be influencing calculations of mapping distances. However, to ...
Genealogists have used these tests routinely since their inception as a tool to help with their family history research, both to confirm existing relationships and find new relatives [3]. Such tests are also used in unknown parentage searches [4], [5], with thousands of adoptees, donor-...
The combined use of these three resources provides a powerful tool for Marker Assisted Selection. It gives comprehensive knowledge for the selection of subsets of SNP markers to use from polymorphism, mapping and hierarchical information. Finally, the proposed resources will undoubtedly help in directing...
The software will use linkage map and QTL information to simulate marker type and phenotype, which are then used for QTL mapping. Fig. 8 shows the interface of the BIP functionality. At top are the menu and tool bars. At left is the project window. At middle right is the input file ...
The steps involve pre-processing (to correct the search format), searching related information based on RefSeq ID / UCSC ID, and mapping the positions of transcripts to the genome. These steps can be strung together in custom ways, but a tool able to perform all steps in a single ...