This invention relates to a novel method for genetic linkage analysis and identification of a mutated gene by mitotic recombination. In particular, this invention relates to a method for genetic linkage analysis and identification of a mutated gene linked with the rare autosomal dominant disorder ...
In most cases, recombination will occur frequently, indicating that the disease allele and the marker are far apart. Markers in close proximity, however, will tend not to recombine with the disease gene; in this case, the marker and the disease allele are said to be in “linkage ...
Linkage data using the markers DXS51, F9, DXS15, and DXS52 are presented from 14 pedigrees segregating with the fragile X. Cytogenetic and DNA data were combined by two- or three-point linkage analysis for estimation of lod scores and carrier probabilities in potential carriers. Recombination fr...
Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks. PLoS One 8, e85075 (2013). Article ADS Google Scholar Liu, E. Y. et al. High-resolution sex-specific linkage maps of the mouse reveal polarized ...
This result is here extended to allow for the effect of linkage, and it is shown that the change in the variance is effectively determined by the harmonic mean of the recombination fractions. The validity of the approximate general formula derived here has been checked by comparison with exact ...
A genetic linkage map for the salmon louse (Lepeophtheirus salmonis): evidence for high male:female and inter-familial recombination rate differences Mol. Gen. Genomics., 294 (2) (2019), pp. 343-363, 10.1007/s00438-018-1513-7 View in ScopusGoogle Scholar Davidson, 2010 E.H. Davidson Emer...
It is derived under the sole assumption that selection is weak enough relative to recombination to ignore linkage disequilibrium. In particular, necessary and... R Bürger - 《Journal of Mathematical Biology》 被引量: 209发表: 2005年 Association mapping for enhancing maize genetic improvement Associat...
G. Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum. Hered. 56, 18–31 (2003). Article PubMed Google Scholar Spencer, C. C. A. et al. Designing genome-wide association studies: sample size,...
Physical linkage between genes underlying male-female communication (i.e. sexual signals and preferences for them) facilitates both rapid and coordinated divergence of sexual communication systems between populations and reduces recombination in the face of occasional hybridization between diverging populations...
2018), a subset of SNPs was selected by linkage disequilibrium (LD)-based SNP pruning using PLINK for genetic diversity and population structure analysis. For principal component analysis (PCA), we applied the indep-pairwise command with an SNP window size of 50, 5 SNPs shifted per step, ...