Inheritance patterns in the latter can be explained by a polygenic heterogeneity model, involving a dosage effect resulting from the combined effect of both common and rare variants of susceptibility genes. The
Traits that do not follow Mendelian inheritance patterns and are derived from any combination of multiple genetic factors, environmental factors and their interactions. Single nucleotide variants (SNVs). Single base pair positions in the genome where there is variation across individuals. SNVs need not...
Ordination plot for the first two principal component axes resulting from a discriminant analysis of principal components (DAPC) for each individual, ellipses indicate their assignment to the genetic clusters inferred. The low-right graph indicates the variance explained by the principal component axes ...
(or internally via resampling). Since different studies use different variables, clustering techniques, and several clusters, the results tend to vary. This may in part be explained because similar data is not always available and selection bias may occur (e.g., patients withcognitive impairment...
gigas is known to have a high genetic load [42], such distortions in these bivalves have been explained by zygotic viability selection due to the presence of deleterious recessive genes [9, 11, 12]. Segregation distortions reported here may also be attributed to the presence of deleterious ...
Whereas mutation inSAMHD1is a common somatic event in a variety of cancers47, we demonstrate here that it is also a germline risk factor. Recessive inheritance ofSAMHD1missense variants and PTVs have been associated with Aicardi–Goutières syndrome, a congenital autoimmune disease48. The damaging...
Qualitative studies have observed that individuals have difficulties in understanding, or accepting, inheritance patterns [23]. People also adopt various lay models of inheritance, thinking that they are more likely to inherit a genetic susceptibility from family members, who are "like" them in terms...
(Supplementary Fig.9). Overall, the predictive power of PRS is not high, in line with earlier discoveries involving raw imaging-derived phenotypes, as demonstrated in ref.13. The authors developed PRSs for seven selective brain regions, which explained roughly 1.18–3.93% of the phenotypic ...
explained = 0.20%) and suicide thoughts (maximum variance explained = 0.13%) (Fig.3). Although the PRS forself-harm behaviourdid not predict NSSH in our sample, the PRS forself-harm behaviourwas predictive of broad sense self-harm (regardless of suicidal intent; maximum variance explained ...
To date, four large extended multiplex families of diverse racial/ethnic backgrounds have been described that exhibit familial clustering of IgAN with differing clinical features and at least two different putative genetic inheritance patternsTable 4. Julianet al first described 14 patients with biopsy-...