L. (2004). A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. American Journal of Medical Genetics. Part A. 131, 1-10.Jiang YH, Sahoo T, Michaelis RC, et al. A mixed epigenetic/ genetic model for oligogenic inheritance of autism with ...
Additional studies of genome- wide DNA methylation in larger ASD cohorts, integrated with genomic, transcriptomic, proteomic as well as the phenotypic mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A. Am J Med Genet A 2004; 131: 1–10. 16 ...
Autism, which affects about one percent of the population, is a developmental disorder thought to be caused by a complex interplay between genetic and environmental factors. Although the disorder is highly heritable, the majority of autism cases cannot be attributed to known inherited causes, Dr. B...
Autism: Comparative Genomics and Interactomics Many common human neurological disorders, including autism spectrum disorder (ASD), epilepsy, Alzheimer's disease, attention-deficit/hyperactivity disorder ( ADHD ), and schizophrenia, have complex genetics and inheritance patterns. Whil... C Barth,N Bishop...
(A-D) Rare inherited coding variants by consequence and inheritance. The rate of rare inherited coding variants per fully phase-able child is displayed for 960 affected (red) and 217 unaffected (blue) children by both variant consequence and inheritance, this includes newly hemizygous variants in...
The precise patterns of inheritance of these complex disorders have not been determined, nor have the relevant genes been localized or cloned. Because the genetics are complex and because there is also clearly an environmental contribution to behavior, we expect the analysis of the genetics of ...
In view of the main results of this review, the whole family must be considered in patient follow-up, both at a genetic level (genetic inheritance pattern) and at a psychosocial level (psychoeducation, transmission guilt, coping with stigma). As Chaumet said in 2006, "genetic diseases are ...
Small effect sizes characteristic of non-Mendelian traits, polygenic patterns of inheritance and true heterogeneity between studies confound attempts to reach a consensus regarding the role of common polymorphisms in contributing to personality domains. Nevertheless, the current state of personality genetics ...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic component whose knowledge evolves quickly. Next-generation sequencing is the only effective technology to deal with the high genetic heterogeneity of ASD in a clinical
1.An interaction between nonallelic genes in which the genotype at one locus affects the expression of alleles at another locus. 2.A film that forms over the surface of a urine specimen. 3.The suppression of a bodily discharge or secretion. ...