Sixty-six percent of patients had a clinical diagnosis of a cardiomyopathy, 28% a primary arrhythmia, and 0.7% congenital heart disease. The reason for diagnosis was most commonly as a result of investigations of symptoms (73%). Most patients were referred by a cardiologist (85%), followed ...
These individuals were followed up for 3 years and there has not been any cardiac clinical symptoms, cardiac death or excessive bleeding reported. Conclusions: Given the varied effectiveness of clopidogrel due to its metabolism by CYP2C19 enzyme, and the relatively high frequency of both gain-of-...
From a clinical perspective, neurodegenerative diseases are often also defined in terms of their predominant symptom (e.g. AD by memory impairment or PD by parkinsonism), but in reality, present as highly heterogenous diseases, with symptoms spanning multiple domains including neuropsychiatric symptoms6...
Structural heart disease with current or past symptoms of heart failure Patients with known structural heart disease and shortness of breath and fatigue, as well as reduced exercise tolerance The majority of patients with heart failure are in this stage Corresponds with NYHA classes I, II, III an...
(MDD), heart disease, and cardiovascular disease. We also observed associations between these loci and other diseases (e.g., anemia), as well as biomarkers from various human organs (e.g., liver) (Fig.2B). We then performed positional and functional annotations to map SNPs to genes ...
Genetic disorders are conditions that have some origin in an individual's genetic make-up. Many of these disorders are inherited and are governed by the same genetic rules that determine dimples and red hair. However, some genetic disorders—such as Down syndrome, characterized by heart malformatio...
Everleigh has all the main symptoms of Turnpenny-Fry syndrome, which include distinct facial features, developmental delays, heart and skeletal abnormalities, and smaller-than-average size at birth and throughout life. Characteristic facial features include a bulging forehead; sparse, slow-growing hair...
The article focuses on the relationship between genetic and environmental risk factors in psychiatric disorders. According to the authors, schizophrenia and coronary heart disease share some of the same environmental risk factors. However, the authors assert that the ability to detect differences by comp...
Familial hypercholesterolemia (FH) is an inherited disorder characterized by raised serum LDL cholesterol, which leads to accelerated atherosclerosis and a steep rise in the risk of premature coronary heart disease. Here, Anne Soutar and Rossi Naoumova e
their cumulative impact expressed in PRS confers a more substantial risk for the disease [8,74,75]. Findings from recent studies suggest that PRS may become a useful tool in psychiatry for both diagnostic and prognostic purposes. For example, patients with psychotic symptoms, as well as their ...