Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by significant impairments in social, communicative, and behavioral abilities. However, only a limited number of studies address the genetic basis of ASD in the African population. ...
Genetic factors in etiology of autism spectrum disorder and early onset schizophrenia: Two sibling casesH., BilgicA., IrmakB., InceTasdelenD.B., Oztop
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental abnormalities characterized by stereotypical communicative and social impairments, affecting 1 in 88 children in the United States. Both genetic and environmental factors contribute to the etiology of ASD. Autistic traits may be...
To calculate the genetic predisposition (risk) of our target sample to the traits of interest, each variant’s effect size was obtained from the GWAS summary statistics. Our PRS estimation pipeline excludedindels, strand ambiguous- and low (R2 < 0.6) imputation quality-variants. The most si...
Zero order kineticsDrug elimination is independent of the drug's concentration Physiological factors •AgeLower doses are required in both infants and the elderly, in the former because the metabolic machinery is not fully operational, in the latter because the machinery is decaying, with ↓ cardi...
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals (nmax = 12,893) based on core and associated features of autism, co-occurring developmental disabilities and...
Zhao adds, "By jointly analyzingde novomutations fromcongenital heart disease(CHD) and autism, we identified novelgenesthat may play an important role in explaining the shared genetic etiology of CHD and autism." Yuhan Xie, the lead student of the research, says, "As a biostatistics student, ...
Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism Distinguishing the specific genetic etiology using clinical characteristics alone is not possible and genetic testing, often performed sequentially until a pathogenic mutation is found, is essential for accurat...
But under the radar, geneticists are moving in the opposite direction, parsing the disease into more specific subtypes on the basis of its molecular etiology. Autism is not a biological disorder, but rather a behavioral description, with the underlying disease “a constellation of rare genetic ...
J. (2013). Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: Guideline revisions. Genetics in Medicine, 15(5), 399–407. https://doi.org/10.1038/gim.2013.32 Article PubMed Google Scholar Schaefer, G. B. (2016). Clinical genetic aspects of asd spectrum ...