When you think about what you'd want to inherit from your parents, you're probably thinking about money, property, or cool vintage jewelry - you're definitely not thinking about genetic diseases you can inherit. Unfortunately, there's a plethora of nasty genetic disorders that ...
The overall pattern of loneliness–disease associations in the UK Biobank dataset was largely consistent with that observed in the CHARLS and HRS datasets. Across these two supporting cohorts, loneliness had the strongest association with mental and behavioural disorders, followed by associations with ...
we identify 62 loci of which the same allele is significantly associated with both higher adiposity and lower cardiometabolic risk. Functional analyses show that the 62 loci are enriched for genes expressed in adipose tissue, and for regulatory variants that influence nearby genes that affect adipocyte...
Over the past decades, NA drugs including DNA- and RNA-based therapeutics, have been widely exploited to treat a wide range of diseases, especially genetic disorders, and cancers. The first attempt to deliver a gene coding for resistance to neomycin into lymphocytes harvested from cancer patients ...
There has recently been marked progress in identifying genetic risk factors for major depression (MD) and bipolar disorder (BD); however, few systematic efforts have been made to elucidate heterogeneity that exists within and across these diagnostic taxa. The Affective disorders, Environment, and ...
I am forced to tell you here, O people whose blood is mixed, if you are fleeing, if you disdain, if we refuse to ally with you, is it not because of your bad conduct, scandals & disorders that reign openly among those of this caste, more than among the others? Indeed, have we ...
common disorders; genetic testing; predictive value; monogenic subtypes; public health INTRODUCTION Background and purpose During the years prior to the turn of the century, scientific and medical attention for genetic disorders was mainly focused on under- standing rare single-gene disorders, such as...
We then performed a linear regression analysis between plasma sST2 level and AD and its related endophenotypes, adjusting for age, sex, status of cardiovascular diseases (CVDs; that is, heart disease, hypertension, diabetes mellitus and hyperlipidemia), body mass index (BMI) and education level, ...
Both conditions affect the red blood cells containing the protein haemoglobin which carries oxygen from the lungs to all parts of the body. Thalassaemia can lead to severe anaemia requiring lifelong treatment. In sickle cell disorders, severe pain and damage to organs such as the liver, kidney, ...
playing a significant role in the body–brain connection and its impact on cognition. Additionally, exercise can influence gene expression through epigenetic mechanisms, leading to lasting improvements in brain function and behavior. Herein, we summarized various genetic and epigenetic mechanisms that can...