When contemplating pregnancy, either parent affected with an autosomal dominant disorder. Aetna considers appropriate genetic counseling unrelated to pregnancy medically necessary for consideration of, or provided in conjunction with, medically necessary genetic testing, and in accordance with the guidelines of...
Carrier screening of female reproductive partner planning a pregnancy and has family history of SBMA; or Prenatal testing in the offspring of the biological parent with confirmed AR CAG trinucleotide repeat mutation. Aetna considers genetic testing for SBMA experimental, investigational, or unproven for ...
The fourth locus was a SNP in chromosome 12, in an intron ofNUAK1(rs12146713,β = −0.10,P = 1.26 × 10−9), and remarkably its top association in UK Biobank was with the contrast between schizophrenia and major depressive disorder10, and it was also associated with i...
This document focuses on genetic testing and screening in common disorders. The term 'common disorder' is used for disorders that individually have a high impact on public health. Examples of common disorders include cardiovascular disease (CVD), stroke, diabetes, cancer, dementia, and depression. ...
At the DNA sequence level, further investigation of variants of unknown significance is an opportunity for exploration of biologic pathways of importance to pregnancy loss. This review concentrates on SLO as an example of a single gene disorder with a high carrier but low affected liveborn proband...
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical specialties. Previous GWAS indicated high genetic correlations between tinnitus and hearing loss, with little indication of differentiating signals. We present a GWAS
To determine whether sequence variants with a strong deficit of homozygosity resulted from losses early or late in pregnancy, we examined the reproductive history of heterozygous carrier couples, looking for an excess of miscarriages or early death among their offspring. Also, we assessed the effects...
and early-life environmental stresses, such as maternal smoking in pregnancy46. Gender was reported to play an important role in asthma as well; in females, asthma appears to be predominantly adult onset rather than pediatric47. More generally, investigators suggested that, in asthma, disease onset...
On the other hand, the inci- dence and prevalence of CAD are high in a first world popula- tion, and therefore, it is not uncommon for a DCM gene carrier to also have CAD, confounding family history assessments. Because of the age dependency of CAD, we treat any unex- pected death ...
(95% CI 1.11–1.31 and adjustedP = 2.3 × 10−5), respectively. However, no significant difference in HRs for this mental disorder was observed between subtype 2 and subtype 4. Additionally, all three subtypes, when compared with subtype 4, exhibited higher risks for anxiety (...