Human genetic disease is any of the diseases and disorders that are caused by mutations in one or more genes of the human genome.
The genetic architecture of common diseases is central to the scientific and clinical goals of human genetics because it directly impacts biology, disease screening, diagnosis, prognosis and treatment. Genetic architecture is currently assessed by exploiting the differences in types of genetic variants asc...
Drug abuse, including the use of cannabinoids, upregulates dopamine concentration in the mesolimbic regions of the brain, such as the nucleus accumbens [111]. D-9-tetrahydrocannabinol (THC), the active cannabis compound that interacts with C1BR in humans, has been indicated to reduce the release...
diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated...
Genetic epidemiology of infectious diseases in humans: design of population-based studies. Emerg Infect Dis. 1998 Oct-Dec;4(4):593-603.Abel L,Dessein AJ.Genetic epidemiology of infectious diseases in humans: design of population-based studies.Emerging Infectious Diseases. 1998...
However, there are very few clinical reports on the pathogenicity of PDCoV in nursery pigs. Here, we recorded an outbreak of PDCoV in a large nursery pig farm which raised about 7000 pigs. The diseases lasted more than 3 months and almost all of the pigs were infected. Finally, ...
A.It’s possible to have home blood test every day in the future. B.Home blood test can provide accurate result to cure diseases. C.Healthy young people needn’t have home blood test very often. D.The company Cor often misleads people by giving false results. ...
“This work can be translated in human patients clinically,” Stitelman continued. “This approach could be used for most diseases where a known genetic mutation causes the disease. Many of these diseases are devastating and currently without cure. Our approach corrects the disease at the most fu...
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Nat. Rev. Neurol. 17, 157–172 (2021). Article PubMed Google Scholar Stephenson, J. et al. Inflammation in CNS neurodegenerative diseases. Immunology 154, 204–219 (2018). Article PubMed PubMed ...
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels acr...