Asthma and allergic diseases are complex conditions with both genetic and environmental causes, and their incidence is increasing worldwide. Several hundred genes have been associated with asthma through candidate gene studies, but most of those results have either not been replicated or have failed ...
A. et al. Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat. Genet. 49, 1752–1757 (2017). Article CAS PubMed PubMed Central Google Scholar Wijmenga, C. & Zhernakova, A. The importance of cohort studies in the post-GWAS era. Nat. Genet...
One important limitation: Different studies don’t all implicate the same genes in asthma, so it’s difficult to know which ones are true changemakers—or whether it’s a combination of certain genes that causes asthma to develop. Plus, some genes may be unique to certain types of asthma, ...
Forest plots for MR analysis of different levels of obesity and different allergic diseases. A-C: obesity class I and childhood allergy (age < 16), allergic asthm a, atopic dennatitis. D-F: obesity class 2 and childhood allergy (age < 16), allergic asthma, atopic dermatitis. G-1: obes...
The PSMD3–CSF3 locus and the major histocompatibility complex class II region have been implicated for rheumatoid arthritis, an autoimmune disease charac- terized by inflammation of the joints.59–62 The PSMD3–CSF3 locus is also a well-known risk locus for asthma.63 The ERG locus, one ...
What genetic mutation causes anencephaly? Which type of chromosomal mutation causes Klinefelter Syndrome? What type of chromosomal mutation causes Down syndrome? What genetic mutation causes asthma? What genetic mutation causes fragile X syndrome?
tripled between 1997 and 2008, according to a report from Mount Sinai School of Medicine in New York. “国际儿童哮喘及过敏研究”(International Study of Asthma and Allergies in Childhood)是一项全球性的调查,其数据显示,1998年在发达国家中,只有约20%的孩子患有哮喘、过敏和疹子等过敏性疾病。纽约...
KIF3A is a gene that codes for a protein involved in generating signals from the outside to the inside of a cell, part of a complex sensory apparatus. Previously, scientists had identified an association between two genetic variations in KIF3A and asthma in children who also had eczema. In ...
Although it has been established that immune phenotypes have a shared genetic predisposition, further detailed and systematic analysis is necessary to understand the causes and structure of such sharing. In particular, it is unclear whether sharing is equally distributed across immune diseases (i.e. ...
Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry