acts towards NF-kB inhibition, this deubiquitinase might impair platelet responses decreasing the risk of thrombogenesis85,86,87,88,89. However, no study has yet validated the role of rs7164569 in cancer-related VTE4. As the NF-kB signalling pathway is implicated in several processes associated ...
Canon Medical Systems USA is introducing a new configuration of the Aquilion One / Genesis Edition – the Aquilion One / Genesis SP. The vendor said this is a completecardiac CTsolution that is designed for the evolving needs of structural and coronary imaging, enabling consistent, high-quality...
In cell culture studies, blockade of LRP5 signaling decreases tumorigenicity of prostate cancer PC-3 cells, and drives a mesenchymal-to-epithelial transition in PC-3 and SaOS-2 cells. Moreover, dominant-negative LRP5 (dnLRP5) caused considerable inhibition of tumor growth, invasion, and ...
Metformin alters H2A.Z dynamics and regulates androgen dependent prostate cancer progression. Oncotarget 9, 37054–37068 (2018). Article PubMed PubMed Central Google Scholar Tseng, C.-H. Metformin use is associated with a lower risk of uterine leiomyoma in female type 2 diabetes patients. Ther...
The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion J Immunother Cancer, 7 (1) (2019), p. 58 View in ScopusGoogle Scholar 5 Q. Li, O. Wijesekera, S.J. Salas, et al. Mesenchymal stem cells ...
Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. Clin Cancer Res 11 (9): 3250–3256, 2005. Article PubMed CAS Google Scholar Edwards J, Mukherjee R, Munro AF, Wells AC, Almushatat A, Bartlett JM. HER2 and COX2 ...
Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany Anna-Lena Illert & Cornelius Miething Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Bonn, Germany Martin Braun & Sven Perner Biotechnology Centre of Oslo, Oslo, Norway...
Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 me
(EZH2), in cancer53. As apolycombprotein, the role of EZH2 depends on cofactors that differ by cell context and dosage53. In addition, the oncogenic activity of EZH2 in castration-resistant prostate cancer cells ispolycombindependent but dependent on EZH2 phosphorylation at Ser54. Although DOT1L...
Hospitals, in developed countries the center of curative health care in practice, research, and education, still have a dominantly pathogenic orientation. Therefore, salutogenic principles definitely have to offer quality improvement of cure and care in