So, identification of genes responsible for lung cancer is a major challenging task. This detection of genes can be done using gene–gene interaction network where each node represents a specific gene, whereas interconnection between them is considered as edges. Here, in this work, we have ...
associated with greatly increased risk for lung cancer in nonsmokers6. Individuals with this mutation do not respond well to first-generation EGFR therapy7and a targeted approach is required for individuals carrying this mutation8. Similarly, identification of germline mutations inBRCA1andBRCA2led to ...
Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer Congcong Chen Yang Li Hongbing Shen Nature Communications (2025) Novel genetic markers for chronic kidney disease in a geographically isolated population of Indigenous Australians: Indivi...
The clinical progression of human breast cancer almost certainly reflects accumulated molecular defects in specific genes that are important in regulating normal breast tissue growth and development. These specific defects may occur in association with g
Chronic benign respiratory diseases due to the fungus Microsporum canis probably accounts for the high incidence of lung cancer in northern Thai women at Sarapee. Diets rich in fruits, leafy green vegetables, and vitamin A are protective, while cured meat (Chinese sausage, pressed duck and cured...
Latest statistics from national tumor register center shows that 271 in every 100,000 people develop cancer in China. In 2013 alone, 2.2 million Chinese died of cancer. Lung, liver and gastric cancer were the top three killers.
the drug susceptibility testing for the main pathogens was carried out by using disk diffusion method,the drug resistance genes in the main bacteria were detected with PCR.RESULTS The main pathogens involving in the pulmonary infections combined with lung cancer were as follows : gram-negative ...
Grainyhead-like 1 (GRHL1) is a transcription factor involved in embryonic development. However, little is known about the biological functions of GRHL1 in cancer. In this study, we found that GRHL1 was upregulated in non-small cell lung cancer (NSCLC) an
The aim of this study was to investigate the mRNA expression levels of multidrug resistance-associated proteins in chemo-nave metastatic lung cancer cells ... M Rijavec,M ?Ilar,N Triller,... - 《Pathology & Oncology Research》 被引量: 117发表: 2011年 Genetic diagnosis for chemosensitivity wit...
5a). UBXN2A encodes a ubiquitin-like protein involved in proteasomal degradation32 and CYP7A1 encodes the enzyme (cholesterol 7 alpha-hydroxylase) responsible for the first and rate-limiting step in bile acid biosynthesis in hepatocytes33. At this locus, only one regulatory variant was prioritized...