Researchers identify genes involved in the inheritance of osteoarthritisOSTEOARTHRITISJOINTS -- DiseasesDISEASE susceptibilityGenetic aspectsResearchers identify genes involved in the inheritance of osteoarthritis. By - Alison Palkhivaladoi:10.1016/S0140-6736(02)08254-5Alison Palkhivala...
5. In particular, they even consider synovial inflammation a secondary change in the pathogenesis of osteoarthritis6. In addition, the intensity of research
To identify new candidate genes in osteoporosis, mainly involved in epigenetic mechanisms, we compared whole gene-expression in osteoblasts (OBs) obtained from women undergoing hip replacement surgery due to fragility fracture and severe osteoarthritis. Then, we analyzed the association of several SNPs ...
Although the extracellular matrix (ECM) is the functional element in articular cartilage and its degradation is central in the pathogenetic process in osteoarthritis (OA), increasing the knowledge about the cellular OA phenotype is essential. The aim of this study is therefore to provide a more com...
Knee osteoarthritis (KOA) is a common chronic joint disease globally. Synovial inflammation plays a pivotal role in its pathogenesis, preceding cartilage damage. Identifying biomarkers in osteoarthritic synovial tissues holds promise for early diagnosis
Phosphocitrate (PC) inhibited calcium crystal-associated osteoarthritis (OA) in Hartley guinea pigs. However, the molecular mechanisms remain elusive. This study sought to determine PC targeted genes and the expression of select PC targeted genes in OA menisci to test hypothesis that PC exerts its ...
Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression Authors: Giuseppe Musumeci, Flavia Concetta Aiello, Marta Anna Szychlinska … RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage Authors: Rodrigo Coutinho de ...
Connexin43 enhances the expression of osteoarthritis-associated genes in synovial fibroblasts in culture. BMC Musculoskelet Disord. 2014; 15 :425.Gupta A, Niger C, Buo AM, Eidelman ER, Chen RJ, Stains JP. Connexin43 enhances the expression of osteoarthritis-associated genes in synovial fibroblasts ...
Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis Synovial MembraneOsteoarthritisHypertrophyTransforming Growth Factor betaTrans-ActivatorsMembers of the TGF-尾 superfamily are important regulators of skeletal...
Osteoarthritis (OA), also known as degenerative arthritis, is a chronic disease of the joint characterized by a progressive degradation of subchondral bone [1]. Globally, approximately 250 million people (3.6% of the population) have osteoarthritis of the knee [2]. OA is believed to be caused...