Over the years, the desire for better sports performance has driven many trainers and athletes to abuse scientific research in an attempt to gain an unjust advantage over their competitors. Historically, such e
24,30, and its binding is abrogated following disruption of CKM–Mediator (Fig.2), the observed effect on Polycomb domain interactions in the absence of CKM–Mediator may be due to loss of cPRC1 occupancy. In agreement with this possibility, the effects on cPRC1 binding were related to the...
We find that post2b regulation of effector genes is required for the function of the planarian adhesive organ in the anchoring of the body form to a substrate to initiate transverse fission. Our data support a model in which the coordinate functions of Hox genes regulate asexual reproductive ...
The human mycobiome: colonization, composition and the role in health and disease. J. Fungi 8, 1046 (2022). Article Google Scholar Gutierrez, M. W. et al. Maturational patterns of the infant gut mycobiome are associated with early-life body mass index. Cell Rep. Med. 4, 100928 (2023)...
[13,14]. The half-life of antidepressants in the human body can range from 1 to 2 h for agomelatine, to up to 144 hours for fluoxetine [15] before excretion. Antidepressants are not completely metabolized in the human body and up to 50% (e.g. sertraline) will be discharged ...
(r2 > 0.8) are located in a regulatory element in theSYNE1gene body. This likely enhancer element is marked with the H3K27ac, which is further enhanced in UF fibroids compared to the myometrium, indicating that this regulatory element is further activated in UF.SYNE1encodes a spectrin ...
Throughout medical history, the disciplines of embryology, anatomy, and physiology have provided the biological picture of the human body and the basis for detecting diseases and devising treatments. Despite heightened interest in blood chemistry at the turn of the nineteenth century, as late as the...
Transposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear. Here, we analyze 275 normal colon and 276 colorectal cancer sampl...
Overall effect of gossypol on gene expression in human colon cancer cells To provide a general idea how these genes were regulated by gossypol, we analyzed the pooled qPCR data using BCL2 mRNA as the internal reference and DMSO treatment as the sample control. As shown in the right column ...
A member of the long interspersed transposable element (LINE) family, which is a type of large repetitive DNA sequence that inserts itself throughout the genome through retroposition. L1 retro-elements are∼6,400 base pairs long and are abundant in the human genome. ...