we first performed comparative analysis of genes critical for the development of the pallium (Emx1/2andPax6) and subpallium (Dlx2andNkx1/2) among 500 vertebrate species. We found that these genes have no obvious variations in chromosomal duplication/loss...
The study also found that one of the genetic variants was near genes associated with male baldness, suggesting a tie to sex hormones such as testosterone, and another was in an area rich in smell genes, which have been linked to sexual attraction. But those five DNA markers could explain le...
D Studying the DNA of 300 mice has flagged up genes(基因)which have been linked to hereditary(遗传的) sight loss for the first time. Researchers say because mice's genes are so similar to humans', their findings could lead to the treatment of more genetic diseases.Scientists at the Univers...
2a). Finally, cTWAS accurately estimated the proportion of trait variance explained by the gene effects (Fig. 2a). We also found that PIPs of genes computed by cTWAS are well-calibrated (Fig. 2b and Supplementary Fig. 2). Good calibration means that at PIP > 0.9, we would expect ...
(Fig.3), indicating a strong influence of geographical location on the change of allele frequency across the landscape. After summing the variables' importance, the four MEM variables explained about 48.54% of the model variation, and climate variables explained the remaining 51.46% in all GF ...
The protein components of ribosomes are interesting from several points of view. First, and most obviously, RPs play critical roles in ribosome assembly and function [7]. Second, several RPs perform important extra-ribosomal functions, including roles in DNA repair, transcriptional regulation and apo...
Physical activity is well known for its multiple health benefits and although the knowledge of the underlying molecular mechanisms is increasing, our understanding of the role of epigenetics in long-term training adaptation remains incomplete. In this in
RNA/DNA mixtures and the non-DNase-treated RNA were prepared to construct the RNA-seq libraries using the Ribo-Zero and Poly (A) Selection methods. Each treatment was performed in triplicate, and 36 libraries were prepared. Sequencing data (50-bp reads) were generated using an Illumina HiSeq...
suggesting that gene expression is a reliable intermediary between DNA variation and higher-order complex phenotypes. Starting from this hypothesis, many statistical approaches integrating GWAS and eQTLs summary statistics have been proposed to detect these overlapping associations9,11,12. However, while th...
Among the genes we have identified were both known and new. These two groups differed in the proportion of genes identified using protein-coding SNPs: 39% (15/38) and 5% (8/152) for the new and the known genes, respectively. This difference can be explained by a high impact of GWAS ...