Each mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to
Because the sequenced male inherited his X chromosome from his sequenced female parent, we could use single-nucleotide polymorphisms (SNPs) to infer the complete SLR-X and SLR-Y haplotypes in the sex-linked region (Fig.1b). The X and Y haplotypes’ telomeric repeat regions were assembled into...
Differences in the effects of alleles of the genes Vrd1 and Ppd-D1 with respect to winter hardiness, frost tolerance and yield in winter wheatWinter WheatFrost ToleranceAlternative AlleleAllelic DifferenceVernalization RequirementThe influence of allelic differences between the genes Vrd1 and Ppd-D1 ...
We constructed a genetic risk score by adding the risk alleles per individual weighted by the reported effect sizes. All people underwent cognitive testing. With linear regression we investigated the relationship between the genetic risk score and cognition, with and without APOE. In a subcohort, ...
Hybrids which were homozygous for the BB alleles developed significantly earlier than hybrids which were heterozygous The difference between the age at onset of heterozygous and homozygous hybrids reached a maximum at the loci Ighe on 6 (+ 32 days, p = 0.0018) and D8Mit2 on 8 (+ 28 days,...
In modern terms, the first of Mendel’s laws states that genes are transferred as separate and distinct units from one generation to the next. The two members (alleles) of agenepair, one on each of paired chromosomes, separate during the formation of sex cells by a parent organism. One-...
Run2.1 and Run2.2 triggered a successful immune response when challenged with LNYM and NY19. Curiously, both alleles showed a nonidentical response against Musc4. Specifically, in the case of Run2.1, a weak immune response was observed for this isolate, unlike Run2.2, in which the resistance ...
The fixation index is a single SNP test, which is routinely used for identifying highly differentiated alleles [29]. Genetic differentiation between populations is expected to be low in neutral regions of the genome or in regions under balancing selection, whereas high genetic differentiation indicates...
We did not see evidence of a synergistic effect of being carriers of both SIRT1 and FOXO3 advantageous alleles. 展开 关键词: Effect modification FOXO3 Gene–gene interaction Longevity Sex difference SIRT1 DOI: 10.1093/gerona/glab378 年份: 2021 ...
(Wang et al.2010). Therefore,Wxhas been studied extensively and used widely to improve rice ECQ. Hence, a number of useful naturalWxalleles have been cloned and applied in rice breeding practice. Up to now, about ten naturalWxalleles have been reported, including the newly clonedWxlvandWxmp...