Scientific ReportsRahat B, Mahajan A, Bagga R, Hamid A, Kaur J. Epigenetic modifications at DMRs of placental genes are subjected to variations in normal gestation, pathological conditions and folate supplementation. Sci Rep. 2017;7:40774.
The expression of PRE1, which positively regulates GA signaling and cell elongation in A. thaliana50, was also upregulated in pear buds during the chilling accumulation period. Thus, TCP4 may interact with bHLH proteins to activate PRE1, GA20OX2, and other cell division- and elongation-...
Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. Cancer Sci 2014; 105: 1457-1463.Justin J.-L.Wong, Katherine A.Lau, NataliaPinello, John E. J.Rasko. (2014) Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and ...
While the majority of synthetic small-molecule MDM2 inhibitors have been designed to inhibit MDM2-p53 binding and activate p53, many natural product inhibitors directly decrease MDM2 expression and/or MDM2 stability, exerting their anticancer activities in ...
Somatic embryogenesis (SE) exemplifies the unique developmental plasticity of plant cells. The regulatory processes, including epigenetic modifications controlling embryogenic reprogramming of cell transcriptome, have just started to be revealed. To iden
(I) Transvection is defined as the pairing-dependent ability of an intact upstream regulatory element (enhancer) on one allele to activate the promoter (P) of the other allele. It usually involves a structural mutation in one gene copy and a regulatory mutation in the other (X's) (redrawn...
OVs directly target and kill tumor cells while triggering IFN responses that activate both anti-viral and anti-tumoral immune responses. Red lines: inhibition; blue arrows: activation; doted lines: indirect effect and solid lines: direct effect. 1.1 The IFN family IFNs are part of a l...
3C), it shows that the histone modifications of H3K9ac, H3K4me2, and H3K27ac activate the high expression of this gene in the normal cell line, H3K27me3 inhibits the expression of this gene in the tumor cell line. For the gene ACKR3, it is highly expressed in normal cell line and...
In addition, elevated SAH levels were approved to trigger phagocytosis suppression in MΦ [74] and to activate NF-κB pathways and pro-inflammatory cytokine production in the endothelial cells [75]. This study only connected cacna2d4 induction with DNA hypomethylation in the human AD brain. ...
Then, dCAS9-KRAB hTERT cells were transduced with lentivirus carrying the LV-sgRNA plasmid and were selected with Zeocin (100 µg/mL) until non-transduced control cells were all dead. After selection, cells were induced with doxycycline (2 µg/mL) to activate dCAS9-KRAB. For dCas9...