Moreover, evidence is limited regarding the adequacy of FDA generic standards for AEDs, particularly for "narrow therapeutic ratio" medications such as oxcarbazepine, although two carbamazepine studies are supportive. Most patients can successfully initiate therapy with generic AEDs and can safely switch ...
Methods We used linked electronic medical and pharmacy claims data to identify Medicare beneficiaries who initiated one of five AEDs (clonazepam, gabapentin, oxcarbazepine, phenytoin, zonisamide). We matched initiators of generic versus brand-name versions of these drugs using a propensity score that ...
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Until 2010, the following new drugs were introduced: gabapentin (1 brand name and 2 generics), oxcarbazepine (1 brand name), pregabalin (1 brand name) and levetiracetam (1 brand name). In addition, new lamotrigine (6 generics) and topiramate (2 generics) drugs were included. In 2010, ...