Prazeres P, Almeida VM, Lousado L, Andreotti JP, Paiva AE, Santos GSP, Azevedo PO, Souto L, Almeida GG, Filev R, et al. Macrophages generate pericytes in the developing brain. Cell Mol Neurobiol (in press); doi: 10.1007/s10571-017-0549-2....
Radial glial cells, ubiquitous throughout the developing CNS, guide radially migrating neurons and are the precursors of astrocytes. Recent evidence indicates that radial glial cells also generate neurons in the developing cerebral cortex. Here we invest
BMP-2 and BMP-4, in contrast, inhibit cell division and promote differentiation (including cholinergic differentiation). Thus, a single neuronal precursor cell can differentiate into multiple classes of neurons, and this differentiation can be modulated by environmental signals. 展开 ...
This report chronicles our experimentation with two specific GAL4 lines—OK371-GAL4 and elav-GAL4—both of which inherently exhibit strong red eye pigmentation. OK371 and elav-GAL4 drive transgene expression in glutamatergic neurons and all neurons, respectively10,11, and they also fortuitously exp...
Here, we have investigated the subcellular compartments within which dis- tinct amyloid species are generated and the compartments from which they are secreted. Three experimental approaches were used: (i) immunof luorescence performed in intact cor- tical neurons; (ii) sucrose gradient fractionation...
The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ a... Using a monoclonal antibody against the microtubule-associated protein tau we compared the distribution and the biochemical maturation of this pr...
Medulloblas- tomas were thought to arise from progenitors of granule neurons found in the external granule layer of the cerebellum (Louis et al, 2007). However, researchers have suggested that different subtypes of medulloblastoma arise from distinct progenitor cells, with WNT/b-catenin pathway ...
f. c-Fos staining for active neurons and MAP2 (dendrites) in a 54 + 60 day ALI-CO. Representative image shown of three experiments on three independently prepared ALI-COs with similar results. g. Image of an ALI-CO after 65 days at ALI (125 days total) then placed on the 3D ...
Therefore, we have generated conditional mutants that disrupt the mib1 gene in the developing telencephalon. These mutant mice display complete abrogation of Notch activation, defective RGC maintenance, and premature differentiation to intermediate progenitors (IPs) and finally neurons. These phenotypes were...
The processing elements can be referred to herein as “artificial neural units,”“artificial neurons,”“neural units,”“neurons,”“nodes,” and the like, while connections between the processing elements can be referred to herein as “synapses,”“weights,” and the like. A neuron can ...