Gene-set analysis To perform the gene-set analysis, for each gene g the gene p-value pg computed with the gene analysis is converted to a Z-value zg = Φ−1(1 – pg), where Φ−1 is the probit function. This yields a roughly normally distributed variable Z with elements zg that...
Gene-set analysis的结果 以pathway为对象的sumstats结果 # TOTAL_GENES = 18152# TEST_DIRECTION = one-sided, positive (set), two-sided (covar)# CONDITIONED_INTERNAL = gene size, gene density, inverse mac, log(gene size), log(gene density), log(inverse mac)VARIABLE TYPE NGENES BETA BETA_ST...
We set out to investigate the burden of ultra-rare variants (URVs) in a comprehensive range of biologically informed gene-sets presumed to be implicated in epileptogenesis.#The burden of 12 URV types in 92 gene-sets was compared between cases and controls using whole exome sequencing data ...
GWAS, GMMAT performs score tests for each genetic variant as proposed inChen et al. (2016). For candidate gene studies, GMMAT can also perform Wald tests to get the effect size estimate for each genetic variant. For rare variant analysis from sequencing association studies, GMMAT performs ...
We address these themes using data from two cohorts. The first is the Dunedin Longitudinal Study, a long- itudinal birth cohort of 1037 individuals born in 1972–73 and followed repeatedly until the latest assessment at age- 38 years. Study members gave blood for DNA analysis first at age-...
(GWAS) on the International League Against Epilepsy (ILAE) Consortium cohort, which comprised 15,212 epilepsy cases stratified into six epilepsy subtypes (Supplementary Table2)33. Gene expression levels of these epilepsy risk genes were then derived from the Allen Human Brain Atlas and averaged ...
Using a recessive model, none of the four SNPs showed a significant association with gAgP. Table 3 Associations of the four candidate SNPs with generalized Aggressive Periodontitis (gAgP) in the Greifswald cohort Full size table Analysis for Association with gAgP using adjusted SNP data In the ...
We address these themes using data from two cohorts. The first is the Dunedin Longitudinal Study, a longitudinal birth cohort of 1037 individuals born in 1972–73 and followed repeatedly until the latest assessment at age-38 years. Study members gave blood for DNA analysis first at age-26, an...
We applied the proposed method to analyze a candidate gene-based COGEND study and a large-scale GWAS data on dental caries risk.doi:10.3390/stats4030033Jiayu HuangJie YangZhangrong GuSong Wu