Gene expression in Escherichia coli is controlled by well-established mechanisms that activate or repress transcription. Here, we identify CedA as an unconventional transcription factor specifically associated with the RNA polymerase (RNAP) σ70 holoenzy
In Saccharomyces cerevisiae, the large majority of the genes coding for cytoplasmic ribosomal proteins (RPs) depend on the general regulatory factor Rap1 for their transcription, but a small cohort of them relies on Abf1 regulatory activity. A recent study showed that unlike Rap1, whose ...
The determinant factor shall be the receipt of payment. Cheques and bills of exchange shall only be accepted on account of performance and at the cost of the customer. 4.3 In the case of customers, with whom VITLAB is working for the first time or with whom VITLAB does not work regularly...
The synthesis of mRNA molecules byRNApolymerase II (RNAPII) is a multistep process requiring the interaction of numerous proteins with DNA in the region of the promoter (Chapter 23). However, before the expression of a gene can be initiated, thetranscription factor IID(TFIID) must bind to the...
Big Data (BD) and Artificial Intelligence (AI) play a fundamental role in today’s economy that traditional economic models fail to capture. This paper presents a theoretical conceptualisation of the data economy and derives implications for digital gove
Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG (2011) Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF). Proc Natl Acad Sci USA 108:10484–10489. https:/...
The General Data Protection Regulation, or GDPR, is a comprehensive regulatory framework designed to enhance data privacy standards in the European Union (EU). Since coming into effect in 2018, the GDPR has nearly single-handedly transformed the digit
Existing safeguards (encryption,multi-factor authentication) It can be difficult to track down personal data that is scattered throughout the organization’s network in various workflows, databases, endpoints, and evenshadow IT assets.To make data inventories more manageable, organizations can consider ...
The World Health Organization (WHO) attributes competent Family Physicians (cFP) as a key factor in positively influencing health indicators of a country [1]. Pakistan requires 60,000 cFP by 2030 to improve the primary health system for its population of 220 million [2]. Presently, medical gra...
Reliabilitymanagement14 2.1.3Designworkinglife,durabilityandrobustness14 2.2Principlesoflimitstatedesign15 2.3Basicvariables15 2.3.1Actionsandenvironmentalinfluences15 2.3.2Materialandproductproperties15 2.4Verificationbythepartialfactormethod15 2.4.1Designvaluesofmaterialproperties15 2.4.2Designvaluesofgeometricaldata...