IR is closely linked to a series of metabolic dysregulations, such as lipotoxic insulin signaling, hyperglycemia and dyslipidemia, and adipose tissue dysfunction. These metabolic disturbances are well established by epidemiological or genetic evidence as important causes of cardiovascular mortality and all-...
High BMI and dyslipidemia are known to be the most important modifiable risk factors for the onset of NAFLD. A series of studies have elucidated the associations between BMI and dyslipidemia and NAFLD in the past, among which elevated body weight and dyslipidemia were the most important risk fact...
Moreover, HTN, DM, dyslipidemia, and overweight (BMI ≥ 25) were more frequent in individuals in the third tertile of the TyG index compared with the first one (p < 0.001). SBP (126.59 ± 21.61 vs 117.04 ± 19.64; p < 0.001) and DBP (80.72 ± 11.74...
Type 1 diabetes (T1D) is a chronic autoimmune illness that results in loss of pancreatic beta cells and insulin insufficiency. MicroRNAs (miRNAs) are linked to immune system functions contributing to the pathophysiology of T1D, miRNA-375 is significantly expressed in the human pancreas and its ci...
Accelerated cardiovascular disease is a frequent complication of renal disease. Chronic kidney disease promotes hypertension and dyslipidemia, which in turn can contribute to the progression of renal failure. Furthermore, diabetic nephro... Ernesto L Schiffrin,Mark L Lipman,Johannes F E Mann 被引量:...
We present here a cross-sectional study on the associations between the amount of VAT/SAT and small molecules measured in plasma and urine of about 500 participants from the general population free of T2DM, the metabolic syndrome, hypertension, dyslipidemia or renal impairment. In doing so, we ...
cardiovascular events are caused by inflammation associated with RA rather than traditional cardiac risk factors (such as hypertension, dyslipidemia and cigarette smoking).35,36DMARDs are associated with a decreased risk of all cardiovascular events but this is increased with use of NSAIDs and ...
Objective To determine whether 8-iso-prostaglandin F2α (8-iso-PGF2α) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia]. Methods This was a cross-sectional study of the baseline characteristics of...
However, clinical manifestations of atherosclerosis are primarily observed in the elderly, associated with age-related changes in the metabolome, endotheliosis, immune dysfunction, shortening of telomeres, and other systemic changes in homeostasis [9,10]. Dyslipoproteinemia, dyslipidemia, hyperglycemia, ...